Entrez gene ID | | 80196 |
Official gene symbol | | RNF34 |
Full name | | ring finger protein 34 |
Aliases | | ,CARP-1,CARP1,FLJ21786,RFI,RIF,RIFF,hRFI, |
Gene summary | | The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q24.31 |
Gene position | | 121837902 - 121862155 Map Viewer |
Gene orientation | | plus |
Gene size | | 24254 bp |
Gene sequence |
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OMIM ID | | 608299 |
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