Entrez gene ID | | 815 |
Official gene symbol | | CAMK2A |
Full name | | calcium/calmodulin-dependent protein kinase II alpha |
Aliases | | ,CAMKA,KIAA0968, |
Gene summary | | The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q32 |
Gene position | | 149669403 - 149599054 Map Viewer |
Gene orientation | | minus |
Gene size | | 70350 bp |
Gene sequence |
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OMIM ID | | 114078 |
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