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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CASP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 834 Official gene symbol CASP1 Full name caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) Aliases ,ICE,IL1BC,P45, Gene summary This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq] Location Chromosome: 11   Locus: 11q23 Gene position 104905857 - 104896235  Map Viewer Gene orientation minus Gene size 9623 bp Gene sequence >CASP1:complement(8458651..8468273):Length=9623 GGGAGGAGAGAAAAGCCATGGCCGGTGAGTCTTTTACTGTTCCAAGAACAGGTCCCTGGG AAGAAAGAGTTTTGGAAGGGGCTGGCTCTTCTGGAAGCCATAATTAGCATCTGTGGAAGT TTACTTGAGTAGAAGCAAGGAAAAGGGGGGAGAGGGAGGAGAGAAGGAACTAGAAGATTC TTGCAGACTTTAGAAAGGAAAGGCAAGCCCAGAAAGGAACTGAGGCTTTAGGGGAAGCCT GATGTCATTTTGCAATCTTAATTAAACTCTTACTTACATGTTGAAAGTCTGACAGAGGGT ACAGAATTGGCACAGGAGGAGTACTAGCAGCAGTGGTTCCTAAATGAAATGGGCTATTTC TGCTTCATTACTTTATTAACCAGAGTTAAATAAACATGCGACATAAGAGGATGATCTCTG CTTTCCAGGGACTGATGTGGAAATGGTAAACTCAGTCTTCAGGTCACTCCATGCACATGT ATGGAGACTATTGAGGGAAACAAGTAGGACAGCAATACAGTAAGAAGAGGGATTACCCAA CTGTGAGGAGGGGGACATTTCACTGATGAAATCTAAATGAGGTCACTTTCTGTTGATTAC ATGAGAGGAATATGAGGCTGTTTTCATGATGTGAGAAATCCTTGTGCTCTAAACAGACAA GGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGGTACAATAAATGG CTTACTGGATGAATTATTACAGACAAGGGTGCTGAACAAGGAAGAGATGGAGAAAGTAAA ACGTGAAAATGCTACAGTTATGGATAAGACCCGAGCTTTGATTGACTCCGTTATTCCGAA AGGGGCACAGGCATGCCAAATTTGCATCACATACATTTGTGAAGAAGACAGTTACCTGGC AGGGACGCTGGGACTCTCAGCAGGTAAGGGTCAGTGACTTACACTCAAGTTCACCTAGGG CCTGTCTTCGTGCCTAACATTTGATTTCTTTACTAGTCATGTTAATTGGAAGAAAACTTT CTTATTTCTGGCTTCAGGGCCATATTTCTGTAGCAGGGTCCCTATTGCATGTCCCTTGAC TCTCCTTTGATTCTTTTCCTTAATCCTCAGTGGCACTCTTCTGATTAAAGCTCATTTCCT GTTCTGAGTATGTGGTAGCTCCTTTACTGAAGCTCTTGAGAACCATCTGAAAAGCTTCAT GCTGTGTTTTCCAGTGTTCCTGGCAAGGCAAAATATTTACCTGTGGATTTATTTTTGCTG AGTGCAAGGGGTCTGTAGGCACTTATGTAGTTGTAAAGTCACATGAAGCTTTAAGGTTTA TAATCAAATACTTTTTATAACTTTTCTCCAAAATTTTACCCTCCCAAAAGAATAAAATAT ATTTCAATGATGGCGATACACTCAGAGAACACATTGAACGTATAGAAAAGTGAAGATTTC TAATGGGCTCATTCCTCCAGTTGCCTCCTTGTATTTTCTTTGAGTAAGATCACCTGGTTG CCTGTTACCAGGCTGTGGGTCATGCTGTGAGGCCTGGAAATCCTCCACTTGCAACCCTCC TCAGGCCCAATACAGGGCTCAGGAACTGAGCTGGCCAAATCTCATGACCACTTGGACCTA CCACGTGGTGAGGATGAGAGTTCTGGTGGATTCCCAGTCATTGATGTCTGTGGCACTTCC TAAAGCCACTTCAGAGGGAGATGTTCTTTGAAAGCAAAAGCCTTCTGTTCTAAGGGTTAG GGAAAGCTTATGCCTGTCTAAGCAGACATTGCAGATGTTTCTGTTTTCATCTATGTGTAA TAAACACGTATTTTTCTACCAATGCCTCTTTCATTTTCTACCTCCCACCACTCTCTAAAT TAAAGAACATCTTTAACATTATTTAATGTCAGTCAGTCAGTCAGTGTTATGGGAGAAATT TTTAGTGGGGAGTGTTTTACAGATTGGGGTAAAGTTTTCCAGAGATGATAAGTGACTACT TCAATACCCTTTATCTTTTCATAGATCAAACATCTGGAAATTACCTTAATATGCAAGACT CTCAAGGAGTACTTTCTTCCTTTCCAGGTAATGCTGTTTTTAAAGGAAGAGCATTCTTTG ACCCACATCTTCCTTGACATTAATTTTGTAGGATCAAACGTGGGTAAATGGGCTATGGAG AATTCTCATAGATTGGTCATATAATTTTCTTTTTGTAATCTATTCTGCTTTTGTAGAAAC TGTTTCCACAGCTTCATTATCCACATTTATATTAAAAATTCTGAATCTGTGTCTCAAATC CTGATTACCCAAATAAGTACCAAACTTCATTATTTAAGCCTACTGAAATATTCACTCCCA TCTCCCAGAGACACCTTATTCTAAACTTTCCCAGAGCTGAAAATGCTATACTTCCACACC CTGCTTCTCTTCCGGTTTTGTGTAACTTGGTTATTGGTGCCACCGTCACCAGTTGTTCAA ACCAGGAACTTGAAACTCATATGGGACCCTTCCTTCTCATGCACCTCTAACATTCAACCC ATGGCCAAGTTTTATGCAGGCTTTTCTCAAATTTGGAACCATCTCTCTATTTCTACTTCT ATTATTTTATTAAAGAACCCCTATTCCCATAGTGCACTCTTAAACTTATATCTGAAAGCA ATGTAGAGGCTAGGAATGCAAATTATTTATCAAGTTCAGATATTACTCTACTGAATTTAT TAAGGTTGGGTATCATGAATATTTTCTTAAATGTTTCACAGCATGGGATATTCAATATAT AAAGAAATACTGTATTCTCTACTATGAAAAAATAGCTCAAAAATAACCTAACTACTTCTA GTTTTTTTCTATTGTTTTCACACTTCTTTATGAAGAAATCCAACATTTTATCCAACAAAT GATTATTCTATAATTTTTTCCAATATATCTATTCTAATTCGTTCTTCTCCACATCAGCAC ATTTCATGCTGCCTTTGTTTATCTAACTGATTGTATAACAATTTTTCAAATTTGTTTTTA AAATTAAATATTATTTTTTGCCTTAATAGCTTCTAAAAGATCCTCCACACATCTAGAAAA CTTATTTCTATTTTAAAACAAAGGTTACATTAATTTCTTTAACAAGGACATCACATTGTT GGATTGTGTTGAACCTGTGATGAAATAAAAGGCTCAAGGATTTTCTCACATAAACTCTGT GAAAACATTTCCTCAAGTGTCTGTGCAATGAATGTTTAGTGCTATAAATCCATCTAGTGT GTACCTTGATTTTAGCATTTATCATTATATCTTCATTCTACTTCATATATTCAATATTCA TGTCCTTTCATATGTATACATAGAAGGAAGAGATCCTGAAGGACAGGACAAAGATTCATT AAAAAATATTCCTAGTGCTTACTACCATGTATATTAAGTAAATAAATAAAAAGATAAACA TGTATTTTAAAAAATATTTTAGTAGATTAAATTAAGACCTGATCCCATTAAATTTTATCC TAGGGTTTGAATATTTTGAAAAAAGTTTATATTCTTAACTATTTTATCTCACACATTTTT TGTTTTCTGAGTGTTTTATCAGGCATAGACTTTAAATTTTCCCTTTCTATGTTAGTATCT AAAATGCTTGTAGAAAGGCTGATCCTGAAATATGAAAGAAGATACTTGTAATGCATACCT GGAAATCTCTTGCTTGAAATGTGCTCCATTAGGAGCAAACTCACTCAGCTGTGTTAATGA TGTAGATCAGGATTGTCCTCCTCAGAGTGCATTTCCTCTTCTGTGGCTTCATCCATAGGT GAGGCTGTAACAAACACAAAGTGGAACAAACAGGGATGCCACTGTTCATGATGTTCTTTG TCTCTTGCAGCTCCTCAGGCAGTGCAGGACAACCCAGCTATGCCCACATCCTCAGGCTCA GAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAAGCTCAAAGGATATGGAAACAAAAGTCG GCAGAGGTGCCATGCTCAGAACCCAAGGATAGAGTGGGGTGAAAGAAACACTTCAGGCAG TTCTGAAATGCAGTGGCTTATTCTTAGAGCCAACCTCATTGAGCAGTTCTGGAGAATCAT ACTTCTGCTCCCCTTACATAAAGGATTTCTATATCCTAGAATCCCAGGTTTATAGAAAGA GGTCCAAATTGGATCCACTTCCGGGGTAAATAACATCAGTGATGACAGCTATTGAATGCT TATTAAGAATGGGCATTGTTCTAAGCATTTTGCACATGATAATATATAATTTTTAACCTT AAACACAACCCATTTTAGAGATCAAGAAGCTGAGACGGGATTGTTAAATATTTTTCCCAA AGAAAAACAATCAGAAATTGGAACAATCAGTTTTAGAATTCAGTCATTTTTGCTTCAAAG CTTGTGCATCTTTCAAAATCCTACCTATCAAGAACAACGAAGTCAGAAGCTCAGCTGCCA TCTGGGCATTTGCAATGTCCATGCATACTCTTGAAGCAGCATTCAATTCTGTTCCCCCTT TTCAATGTATGGTTCATGGGGTTTGGTATCTTGATAGGACTAAGGAAGGGGAAGCTGTCA TAAACCAGGAAGGGAAATATTTAATTGGAAAGAACAAGGCTGTTCATTCAAATTGCATTT CCTACAGATTTATCCAATAATGGACAAGTCAAGCCGCACACGTCTTGCTCTCATTATCTG CAATGAAGAATTTGACAGTATTCCTAGAAGAACTGGAGCTGAGGTTGACATCACAGGCAT GACAATGCTGCTACAAAATCTGGGGTACAGCGTAGATGTGAAAAAAAATCTCACTGCTTC GGTAAGTTCTATTATACAACAGAAACAATGGTTATGCCCTTCGTATAACTGAATAATATT AGAAAGCTTGGTTGTAAGACCAAGAAATGTAATCTCTTGATAATCTAAAATACAAACTTG CCATGAGAGAGTGCTGGATACTACATGGTCCTTTGTAACATAAGAGTCATGCAGCACAAG CCTGGTATAACTGAATTGGGAAATGTTTTATTGACTCAGTAATGCCACTGTCTCTCTACA AGATAACTCTGGATGACTTCCTATAACACTTTCCTTCACCTTTCTTGAAACTAAGACTAA ATTTTTTTTTGGCACCCTGTTGTTTGTCACGGAATTCCTTAAGAAACTCCTTAAGTATTT ATTTATTGACTTTCCAAGGTACCATGATAGTTAATTACATAGTCGAAAATCAGTGATATG GTGTCTTTCAGGACATGACTACAGAGCTGGAGGCATTTGCACACCGCCCAGAGCACAAGA CCTCTGACAGCACGTTCCTGGTGTTCATGTCTCATGGTATTCGGGAAGGCATTTGTGGGA AGAAACACTCTGAGCAAGTCCCAGATATACTACAACTCAATGCAATCTTTAACATGTTGA ATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGATCATCATCCAGGCCTGCC GTGGTGGTGAGTGCTGATGCCTTTGAGAACACCAGACAATCAAATACTATCCTACTCTGT ATGCATCCAAGAATTTTTGGTTTCTTTTGGTTTGTCTTTTAATGTCAAAGAACACATACT GTCAGTATTCAAGAATGCAGCTTCTGTGAATTGAATGGCTGGTTGGTAGATATTTATTCC ATATTTAAGCTTGAGATTTTGATGTTTGGAAATTTTTACAATTTGTTTGATGGTTAGAAA AGATAAACATTGTTGAAAAGATTGTAACTGAAATGCATGTGTCTATTTGCATGTGAATTA ATGATAGAGCAAACACATTAATAAATATCATTGAACAGAGGCTAGGAGGAAAACATCTTC TCAGCCATTGGTAGTAGTAACAAATCAAACTGTGTCTTTCCAGACAGCCCTGGTGTGGTG TGGTTTAAAGATTCAGTAGGAGTTTCTGGAAACCTATCTTTACCAACTACAGAAGAGTTT GAGGATGATGCTATTAAGAAAGCCCACATAGAGAAGGATTTTATCGCTTTCTGCTCTTCC ACACCAGGTAACAGGTTTCTACACAGGACATCTTTGTTGGGGCTATCAATAGAAAAAGTG ACAATAACCCACTAGAGGTGGTGATTAACAACTCAAGACCAACTCAAGCTTTGTTCCAAG TTATACACAGAATTCCCTTTATCCAAGAGAGCAATTTTGCATATCTGTTCAATGCATTAC TAATTAAAGAATTCATCTATGTTTCAAAATATTTTTGGAACTTTGAGCGATAGCAGAGAA TTAAATGGAAGACGGTATGTGCTGTAGTACATTAGAATCTGACTCTGCATAGAAAATTCT GCCATGTTGAGATCATTCATTAGTCCAATTTGCCCAGACATCAAATATTTATAGGAGAAG AGTAAGAGCAAGATTCTGAAAAGCAGAACAGCAAGCGAGACACTTTGGGGCCCTAAATTA AAGTGGGTTTTACCTAGAAGCATGAAGTGTGTGAGACAGAATATATTTGAATTTTTCTAA ACGTATGCTTTGGAGTAAGAATCTTGCTATTATTGACTGACCCAGACATTTAGTATTTTG TAAAACAGTTCCACTAGTTCCTCCTCGGGCTTTCCTTGAATTGCTGACTAATATGTGAAT ATAAATATTATTTTTCTAAGGATTTAATAAATTAATATATTTGAAATATTGGGCACGACA CAAAATAAAGCACACATTAAAAAACTGCTATTATTTAAAATGTATATATTTGATAACTTA ATTCAGTTACTTTTCTAAGCAAGGTTTAAATAAAAATTATTTAAATCCTTTCATTCACCA CCTTTGGCAGTTTCCTGAGAGGACTTGCATTCTCTTGGTCACCTCTGGCCCAAAGGCCCT GTCTCTGCTCAAATAGTTAAGTTTTCTAAAATATTTTCTAAAATGAGATATCTTCTTTCA GAAGAAGCTTGGTTCTACATTGGGTTGAACATGCCCTGATGTAGAACTCAATAATTTTTT TTTCCCAATGATCAGAAACAATGACACTACCCAAAAACACCATATATTTTCAGCCTGAGT ACGTATAGCAGAGTTTAATATTAGACAGAACTGTTCGTTAGTATCCTTTGATCCCAGCCT TCCACATGACATTCACCGCTCTCTAAGTAGCTCTTTGTAGGCCTCTGGCTTCTCATTATC AATCTGGCTGATTTATGTGTCTTTCTTTTCTTTCACTTTCCTTACTCCTACCTTCTAGAT GACTGTCAGAAACTCCAATTCAGTTATCTATAACTTCCATGTTAAACCTATCTCCACATT CTGCTGTGCCAATCCCAACCACATCATAGTGATCTCCTGAAGAAAAATAATTATCTACTT CCTTAATTTCACAAAACATTTGCAAAGATATCTGTCTCCACGATATCTTTCACTTACTTC CTTTTACTAGAACAAGTCTCAGTTAAAGGCTTCATTTAGCTGAGATAGCTGGGTTTCTAA ATAGAATTTTATTATCAATATATACTTTATGACCATTAGAACTGGCTAAAATGTGTCATT AAAGAATGTGTCTGTCATTACATACAGAGCTATTGCTGCTGCTTTTCTCTTATGACTTCC TTTGCATAATTTTATGCCTTCATTACTTCTGTGTCTACTATGTAATAAATTAATATTTTT CTTTAATATTTCTCTTCTTCATAAGAACTTTTTTCCTCCAATATACTGTGCTTATTTCCT TATCTACTCCTCCTAGATTTCTACTTTTGTTCTGTTTTATGATTTTTATAGTTAACTTTT TGTGTGTAAATATCTTACTGTCAATGTTATTTAATTTCGATTAATCTTTTATGAAGTACA TAAATTGAGAATTTGATAATATAATTACCCCATGTAGACTGAGTATTGCATATCCTGGGT TATCTCAAACACTTGCGTGACCTCAGATACCTCTTGTGTATGGAGTTATTACCATCCCCT GTATAGCTAGCTGAGTCTATTAAATATCAGAATGCATAATTAACTTAAATCACAGTCAGT AATACCACTTTGGGAATGCACATTTAGATATTTCATTTCCAAATCCCAATCACTCCCCTC TACCCCATTCCGCCTTTTCCTTATTTGCTACTAAATTTATGATTTCAAACATCCCTCAGC TGGAGTATAAATACTAGGGTTTCTTCTCTTTCTTCAGGCAAGAGCCAGTCTTGAGATTTG AAATGTGCTTTATCCATAGATAATGTTTCTTGGAGACATCCCACAATGGGCTCTGTTTTT ATTGGAAGACTCATTGAACATATGCAAGAATATGCCTGTTCCTGTGATGTGGAGGAAATT TTCCGCAAGGTAAGATGCTAGTGGATGCTATTTTCACTCTACTTCCCTGAATGCTTGGCT ATTGCAATTGGAAGCATAGAAAGCAGATCCAGACAAGTTTATCTTCCAATAATGCTCTTC TTTCCAAAAGAGTTTTGGAGTTCTTTGGAGAGTGGACAAACCCAGGAGCCTAATCCAATC TATTAAGACCCACAGCCTTGAGAAAACAATCATTTAGTTTCACCCCGCTCCTGCCCTGCA GAGACAAATGAATGGACTCTAATTTACCTGTGTCTCTCATGGCTATTAGATCCAGCAGCA GATTTAAAATGCCCTGAGGAGGGTCATTCAATGCTTACATACATATATGGTTATACTTGT TGCAGATGGAAGTACTTTTTGTTTTTGTCACTTATTTTGCTATATTTGTTGTAGTTTTTT GGCATAACTCAAGAAATTCTTGAAAAAAAAAACTCAGCAAAAAAAAGGGCTACAGACTTT CCTTACTCTTTTAGGTTCGATTTTCATTTGAGCAGCCAGATGGTAGAGCGCAGATGCCCA CCACTGAAAGAGTGACTTTGACAAGATGTTTCTACCTCTTCCCAGGACATTAAAATAAGG AAACTGTATGAATGTCTGTGGGCAGGTACATGTGTATGGTCGGGAGTGTGGGAAGGTTGA GGAAAGGGTACTGAAAGTCCATTTGAGTCAAGAACTCTAGGTTTACAGGCTGAGAATCCT TAATCCAAAAATTTGAATTTTGAAATGCTCTAAAATCCAACACTGTGTGAGCGCCCACAT GATATTCAAAGGAAATGTTTATTGAAACATTTCAAATTATAGGTTTTTGGATTAGGGATG CTAAACCAGTAAGTATACAGCTGAATTCCAATATACAAAAATATCTGAAATTTGAAATAC TTCTGGTAGCATGCATTTTGGATAAGGGATAATCAAGCCATATACAGAAAATACTGAAGT AATGCCTTTCTTCTGGTCAGTGCAGAGCACGTTGCTCTTCTCCCAAAGTTTTTCATTTAG ACCCCTTTTGAGATTCATCTGATATTGGCCTAGAAGTGGCCGTAAGACTACAAACCCTCA CTTTTGGATGTTTCTCTCCTTCACCTCAGCAGGGTATATTTAAACATAGCATGTGGTCTT TCCTTTTAAAATTGTGTATGTTCCCATTGGTGGTATAACTTTATAACTTGCATGTCTTTA ACCAAATTCTTTCCTATGTTTTTTTTTTTAATTATTTCTTTTTCTCATAGGAAGTGAAGA GATCCTTCTGTAAAGGTTTTTGGAATTATGTCTGCTGAATAATAAACTTTTTTGAAATAA TAAATCTGGTAGAAAAATGAAAA OMIM ID 147678