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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SPOP (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8405
Official gene symbolSPOP
Full namespeckle-type POZ protein
Aliases,TEF2,
Gene summaryThis gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q21.33
Gene position47755525 - 47676246  Map Viewer
Gene orientationminus
Gene size79280 bp
Gene sequence
OMIM ID602650