Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ANTXR1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID84168
Official gene symbolANTXR1
Full nameanthrax toxin receptor 1
Aliases,ATR,FLJ10601,FLJ11298,FLJ21776,TEM8,
Gene summaryThis gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq]
LocationChromosome: 2   Locus: 2p13.1
Gene position69240276 - 69476459  Map Viewer
Gene orientationplus
Gene size236184 bp
Gene sequence
OMIM ID606410