Entrez gene ID | | 85363 |
Official gene symbol | | TRIM5 |
Full name | | tripartite motif-containing 5 |
Aliases | | ,RNF88,TRIM5alpha, |
Gene summary | | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11p15 |
Gene position | | 5706339 - 5684425 Map Viewer |
Gene orientation | | minus |
Gene size | | 21915 bp |
Gene sequence |
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OMIM ID | | 608487 |
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