Entrez gene ID | | 8565 |
Official gene symbol | | YARS |
Full name | | tyrosyl-tRNA synthetase |
Aliases | | ,CMTDIC,TYRRS,YRS,YTS, |
Gene summary | | Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p35.1 |
Gene position | | 33283633 - 33240840 Map Viewer |
Gene orientation | | minus |
Gene size | | 42794 bp |
Gene sequence |
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OMIM ID | | 603623 |
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