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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RUNX2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID860
Official gene symbolRUNX2
Full namerunt-related transcription factor 2
Aliases,AML3,CBFA1,CCD,CCD1,MGC120022,MGC120023,OSF2,PEA2aA,PEBP2A1,PEBP2A2,PEBP2aA,PEBP2aA1,
Gene summaryThis gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq]
LocationChromosome: 6   Locus: 6p21
Gene position45296054 - 45518819  Map Viewer
Gene orientationplus
Gene size222766 bp
Gene sequence
OMIM ID600211