Entrez gene ID | | 867 |
Official gene symbol | | CBL |
Full name | | Cas-Br-M (murine) ecotropic retroviral transforming sequence |
Aliases | | ,C-CBL,CBL2,RNF55, |
Gene summary | | The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q23.3 |
Gene position | | 119076990 - 119178859 Map Viewer |
Gene orientation | | plus |
Gene size | | 101870 bp |
Gene sequence |
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OMIM ID | | 165360 |
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