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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MBTPS1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8720
Official gene symbolMBTPS1
Full namemembrane-bound transcription factor peptidase, site 1
Aliases,KIAA0091,MGC138711,MGC138712,PCSK8,S1P,SKI-1,
Gene summaryThe encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq]
LocationChromosome: 16   Locus: 16|16q24
Gene position84150517 - 84087368  Map Viewer
Gene orientationminus
Gene size63150 bp
Gene sequence
OMIM ID603355