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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFSF10 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8743 Official gene symbol TNFSF10 Full name tumor necrosis factor (ligand) superfamily, member 10 Aliases ,APO2L,Apo-2L,CD253,TL2,TRAIL, Gene summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] Location Chromosome: 3   Locus: 3q26 Gene position 172241297 - 172223298  Map Viewer Gene orientation minus Gene size 18000 bp Gene sequence >TNFSF10:complement(78718444..78736443):Length=18000 ACAGAACCCAGAAAAACAACTCATTCGCTTTCATTTCCTCACTGACTATAAAAGAATAGA GAAGGAAGGGCTTCAGTGACCGGCTGCCTGGCTGACTTACAGCAGTCAGACTCTGACAGG ATCATGGCTATGATGGAGGTCCAGGGGGGACCCAGCCTGGGACAGACCTGCGTGCTGATC GTGATCTTCACAGTGCTCCTGCAGTCTCTCTGTGTGGCTGTAACTTACGTGTACTTTACC AACGAGCTGAAGCAGGTCAGTGCAGTGCAGTGCACTCAGTCTTCGAGGCGCTTAGCAAAT GTCTGGTTACCTGCTTCTTTGCATGTCAGCTTGCCCCTCTCTGAAGACTTTCCTGCTTCC TTTCTCTGTGGGTACACTCTAACTGCTAAATCACATAACAACTGAGGTCTTTGCAAAACT GTAAGTTCAAGAAATTGTGTAAACTAAGTGCAGTTACACAACTGGCTTCACTAGTTACTA GCAGATGTGGGCAACAAAACTCCTGAGGGATTTTTTGTTTTTAAAAGTATGTGTATTTTA TAATATCAGCCATTGCAACTCTTCATGAAAGCTTTCTGCTAAATGCTTTGTAGTTCTTTT GTTTTCCTTTTCCAAACTTTTATTTGTGCACATTCAATTGAAAAAGATAATTTTTACAGG TTCTTTGGTGCCCATTTTCAGCATACAAAAATGTAAAAGACTATTCACAGATAAAACACA TTAGCTCAAAATGGAAAAAAATAACAATGACAACAATAAAACAACCTAAGGTAGTGCACA CTGTGACAGCTCTGCTTATGGGGACATGAGAATTCCTGCGAAAATAAATAGAATGTCCTT TTGTAAAAGCAGCAATGACATGTCTTGTAAACTTCCTTTTTTATATTATAACAAGGTTTG GAATAAAATCCAAAGGGACTGGAGCTTACACTGTAGCCATGAATAAATAAAAGAGTCTAT TTCCTCAATTACCGTTGGTTCAGTTTTCCTTTTGAGTCCAATGTGCAGCAGGTTTTAAAA GGTGCACAGTAAGAGATTCTAACCAATTAAGTGGTGAATGATAAAATTTCTTTCCTGCTT TCAAACACAAATGGGTAAATCTGTTCCACAGCAGTAGCAACAGCCTTTAAATAGGGCCTT GTTACTGTGATACTTCCTGTCGAAAAAATCTGTAATGTAGCTCTTAGAGTCTTTATCCAA TAGCACACAGCAGGATGAAGTTCAGATTCATAACTCACATGAGGTCTATTGCTCTTTGTG AATTCTGGCAAACAGATTTCTTTATTTTTAAATTTTTTTATTTTACTTTAAGTTCTGGGA TACGTGTACAGAACGTGCAGGTTTGTTACATAGGTATACATGTGCCATGGTGGTTTGCTG CACCCATCAACCCATCATCTAGGTTGTAAGCCCCACAGGCATTAGGATTTGTTCTAATGC TCTCCCTCCCCTAGCCTCCCACCCCCGACAGGCCCCAGTGTGTGTGTTGCCCTCCCTGTG TCCATGTGCTCTCACTGTTCAACTCCCACTTATGAGTGAGAACATGCAGTGTTTGGTTTT CTGTTCCTGTGTTAGTTTGCTGAGAATGATGGCTTCCAGCTTCATCCATGTCTCTGCAAA GGACATGAATTCATTCTTTTTAATGGCTGCATAGTATTCCATGGTGTATATGTGCCACAT TTTCTTTATCCAGTCTATCACTGATGAGCATTTGGGTTGGTTCCAAGTCTTTGCTATTGT AAATGGTGCTGGAATAAACATATGTGTGCATGTGTCTTTATAGTAGAATGATTTATAATC CTTTGGGTATATACCCAGTAATGGGATTGCTGAGTCAAATGGTATTTCTGGTTCCTTGAG GAATTGCCACACTGTCTTCCACACTGGTTGAACTAATTTATACTCCCACCAACAGTGTAA AAGCATTCCTATTTCTCCACATCCTTCCAGCATCTGTTGTTTCCTGACTTTTTAATGACC ACCATTCTAACTGGAGTGAGATGGTATCTCATTATGGTTTTGATTTGCATTTCTCTAATG ACCAGTGATGATGAGCTTTTTTTCATGTTTGTTGGCCACATAAATGTCTTCTTTTGAGAA GTATCTGTTCATATCTTTTGCCCACTTTTTGATGTGGTTTTTTTCTTGTCAATTTGTTTT ACAAGAAACAAATTCCTTGTAGATTCTGCATATTAGACCTTTGTCAGATGGGTAGATTGC AAAAATTTTCTCCCATTCTGTAGGTTCCCTGTTCACTCTGATGATAGTTTCTTCTGCTGT GCAGAAGCTCTTTAGTTTAATTAGATCCCATTTGTCAATTTTGACTTTTGTTGCAATTGC TTTTGGTGTTTTAGTCATGAAGTCTTTGCCCATGCCATCTTGAATGGTATGCCTAGGTTT TCTTCTGGGGTTTTTATGCTTTTAGGTTTTACGTTTAAGTCTTTAATCCATCTTGAGTTA ATTTTTGTAGAAGCTGTAAGGAAGGGGCCCAGTTTCTGTTTTCTGCATATGGCTAGCCAG TTTTCCCAGCACCATTTATTAAATAGGGAATCCTTTCCCCATTGCTTGTTTTTGTCAGGT TTGTCAAAGATCAGGTGGTTGTAGATGTGTAGTGTTATTTCTGAGGCCTCTGTTCTGTTC CATTGGTCTATGTATCTGTTTCCATACCAGTAACATGCTGTTTTGGTAACTGTAGCCATC TTCCCTGCTTTGTTGTTGCAGGTTGGAGTTACAGTTCTTGACTCATGAATTCTTGAGGGT GAGGGTAGCTGTATCAGAGCTGTGTCTGCTTCTGCTCATTAGTATACCTCTGGGTCTAGC ATGTGGTTCCCAAGTAGCCACTAATACTAATACTTGTGGTTCACTACATACTTATTGAGT GAATGAACAGCCTTCACAGATGTGGTAGGCACCACGAATATGCAGGCGACAAGGGTAGAG TCAGGCTCAACCCAAAGCCAGGCCCTAAGTCACTGAACACTCCCGTTTTGTATTCCAGAT GTAGCTAGTCCTGGTGAACTTTCACATCTTTGAAATGTTTTGCTTTTAGTTATGTGGCAT TCCTGTGTTGACAATAAGTGAGAATACAAAGGACTGGCATTCTGCCTATTCCTGGGGCAC GGGCATGTCATGGGTAAAATCTGTAATAAAGAAGTTATCAGATAGACACAGCTGTTCATG ATAAAACAATTGAAAAGCAAACTGCCAATCTCTGCCTGTGGATGGTCCATGTACAAATTG AGGTATCTTTGACAGACAAAACAAACAAACAGTGCTATTTTAATTTATGATTTTCTCGAT GAAAACCCCTGGAACTATGACTGCAAAATTGCTGAAAATAAACCAACTCAGTTTTTGACT TCTAATATATATTTTAATTCATTGTATATTAAATAGTAGAGAATTATGAGCTGCAAGGAA CGTCAGATCCTCCCCCCACCACCACAACCACTTTTTACAGACGAGGAGACAAGAAATAAT GTACTCAAGTTCAGACAAGGCTTTGGAGGCTGGCCGTGGGGCGGCTAGCACCCAGGTCTG TAGGCTCTTCCCTCCACAGTGGGATGTCCACAGGGTTAACCTATCTACACCTTGTGATGT ACACTGTGCATGCACAGCGCATCCTGCAGCACCAACTCTGCCAGCTGACTAGGAAATGAA AGGCTAAGGATCTCAGAAAAGTATAAATTGTGCAAAAGACATAGAGTAGTAACTATTTGC TAGGGAAATGTAGTTTGCATATCCTGTGGAATGTAAGTTTGGTTATCCCAATCAGTCGGA AATTTTTCTTTTGGAAATGGATGAGGCAGACTCTTGTTTTATTTGCAACTAATTATGAAA ATTATGGCTACTATTAGATGACCAGTAAAGTCAGGTTTATTGTAGGACACATTTAGAAAA GATTTTCTTTTGTAAGAAAAAAATATTAATGAAACTGTAATCATACCTTTAGCTTTAAGT CTACACGAGAGACTGGAATACTGCTATGTTCACCAATTTGGAGCCAGAATTTCCTAACCT TTCTTAACTTTGCAGCATAAACAGAGTAAAGCTGTTACTCCACACACAAGTAGCTCCATC AATTTGCTTACATTACAAGTTGGACTAATTTTAAGATTGAATCAACCAGTTCTTTACTCA ACTGACTCATGCAATTGTCTGTATATATAATCAAATTTCTTTTTCAATTCTACTATAAAA ATGGAAATTTCATATAAGGCTTAAGATCTTCCCACTTGCATACATTTTTCCTAATTGCAT ATTGACATATGAACACATGTACATTAGGCATGCAGAAGAATTCATTGAGAGTGCTAGAAA GCTAGGAGAATTACAGATATTGAGCAATTACTGTGTACCAGCAACTTTGAAAAGTATTGC CTGGTTTCAATTCTCATAACAATTCTATTATGTAAGTATAATTACCCCATATTACAGATG AACAAACTAAAGCTCAGGCGAAGTTAAGAGATTTGTTCAAGATTACAAAACTAGTAAAAG GTAAAACCTGATTTTGAACCCAGGCATGAAGGAGGTACTCAATAAATTGAAGCACCTACT TTTTTTTACAATACATTTTTTCAATACAATACAATGCTATTTTTATAGTAGCGTTCTAAT TACTGCTGAAAAGTCTCCTGAAGGTGTCACTTTCTTCATCAGAAATTTTCCAAAGGGAAA ATAAGTTTGAATCTTCTGTGTAGACTTTGGAAAAGTATATTCAACATAAGTATTAATTTC TTAAAATTGAATACAGGCTCCACTTTGTCTGGTGAACATTTGCAGAAGATACACTCTGCA AGGATTATAGGGTGTAAGGGTTAAGGAAGGCTTCATAACATTGGATTGGACCTTCACAAA TAGCCTGTAGACCAGCAAACATGAACAACAAATATGGGCTTAGCCCCTGAAATCTGTGTC CCTCTGAGAAAGTTTTATGATAAAGGAATGGCCTGTCACTGTGACATCATAGATGGGGAG GAAAAAGGAGAAGGGCTTCCTCTCCACGGATCTCCATAAATGATCCTTTATGCTATTTGC AGTTTGCAGAAAATGATTGCCAGAGACTAATGTCTGGGCAGCAGACAGGGTCATTGCTGC CATCTTGAAGTCTACCTTGCTGAGTCTACCCTGCTGACCTCAAGCCCCATCAAGGACTGG TTGACCCTGGCCTAGACAACCACCGTGTTTGTAACAGCACCAAGAGCAGTCACCATGGAA ATCCACTTTTCAGAACCAAGGGCTTCTGGAGCTGAAGAACAGGCACCCAGTGCAAGAGCT TTCTTTTCAGAGGCACGCAAATGAAAATAATCCCCACACGCTACCTTCTGCCCCCAATGC CCAAGTGTGGTTAGTTAGAGAATATAGCCTCAGCCTATGATATGCTGCAGGAAACTCATA TTTTGAAGTGGAAAGGATGGGAGGAGGCGGGGGAGACGTATCGTATTAATTATCATTCTT GGAATAACCACAGCACCTCACGTCAACCCGCCATGTGTCTAGTCACCAGCATTGGCCAAG TTCTATAGGAGAAACTACCAAAATTCATGATGCAAGAAACATGTGAGGGTGGAGAGAGTG ACTGGGGCTTCCTCTCTGGATTTCTATTGTTCAGAAATCAATATTTATGCATAAAAAGGT CTAGAAAGAGAAACACCAAAATGACAATGTGATCTCTAGATGGTATGATTATGGGTACTT TTTTTCCTTTTTATTTTTCTATATTTTACAAATTTTCTACAGGGAATGTTATAAAAATAT CCATGCTATCCATGTATAATTTTCATACAGATTTAAAGAACACAGCATTTTTATATAGTC TTATGAGAAAACAACCATACTCAAAATTATGCACACACACAGTCTGATCTCACCCCTGTA AACAAGAGATATCATCCAAAGGTTAAGTAGGAGGTGAGAATATAGCTGCTATTAGTGGTT GTTTTGTTTTGTTTTTGTGATTTACTTATTTAGTTTTTGGAGGGTTTTTTTTTTCTTTTA GAAAAGTGTTCTTTACTTTTCCATGCTTCCCTGCTTGCCTGTGTATCCTGAATGTATCCA GGCTTTATAAACTCCTGGGTAATAATGTAGCTACATTAACTTGTTAACCTCCCATCCACT TATACCCAGGACCTTACTCAATTTTCCAGGTTCCTTCCACCTCCTCCTGAAAGTATTTCT GGAAAATACTCAGAAGGGATCACAGGCTCTAGCCAGCAATTGGTGCTAACCTGGGCTAGT CCCTGTGGCACAAGCTCCACCACGACCATCCTTGTCAAACTCCACCTCAGTTGATAAGTT GTTGCCTGCTGCCATTACTGCCTGATCACAGGCAGCTTTCAACTCTGCACCTTGCCTCTC ACAGCTGAAGCCTCCCATATTCAGCCATTTCCTGCTGAGATAGCTTACAGCTGATGTGAA GTGAAAAGGCATACCGCTCCCTCCTTTCTGTGTTATGCACACCTTCTTGCCCCAACAAGT TACAGAGACTTGTGAGCCTGCTTGTTCAGTGTAATCAAACCGAAGCTTGGCCAGAGCCAA CTCATACTGAGTGAACTGGGACAGTGTCCAGGGAAAGTTTGCTCTTCCTGGAACCACCCT CGGGCCTTGTGGCTGATCCCAGTTTCTCGTCTCTTCCTTCTTGATCCTTTCCCACAGTTT GCTAGACATGCTCTCATATTTCTGAATCATATGTGACTGAGTGCCTTCCTTGGAAAGGTT TTGCATCTCCCAAGTCAATTCGAGGTGCAACTGGATGTTTACAGGTGGGGCAGGCAGGGG CAAGGAAATGTACCTAAGTCCATGGCCAGTCATATCTCAACTCAGGAGGCCCCAGCTTCA CCTCCAACTACATATACTACGGGAATGTTTTTCTCTTGTAATTTAAAAGAGGAAGAAACA AAATAAACATTTGTTTAAAAGTAAATGAATGATCTATGTCAGGGTGTGTGGAAGAAATTT ATTAACTCAAGTTTGCACCTTTGCATTTGAGGGACCTTGGCCAAATGTCCAAGGGTTACA TGGCTGAGTACAGAACTGTGTGATTCTAGCTGGGACCTCTCATAAACAGTTAAGATATTT TGATTTAAAATGATATTGTCTTTCTATAGGAAGGAGTGAATCATCGTTCAATTTGATCCT CCCTTCAACCTTTGCAGTACCTTAGTTCAAATAACAGATTAAAATTGTCATTTTCTCATT TATTTCCCTAGGTAGTCAATTCAGCAGATTTTTTTTTTTTTTTTGAGATGGAGTCTCGCT CTGTTGCCCAGGCTAGAGTGCAATGGCACGATCTCAGCTCACTGCAAGCTCCGCCTCCCG GGTTCACACCATTATCCTGCCTCAGCCTCCCAAATAGCTGGGACTACAGGCGCCCGCCAC CACGCCCAGCTAATTTTTTGTATTTTTTTAGTAGAGATGGGGTTTCACTGGGTTAGCCAG GATGGTCTCGATCTCCTGACTTTGTGATTCACCCGCCTCGGCCTCCCAGAGTGCTGGGAT TATAGGCATGAGCCACCGCGCCTGGCCAATTCAGCAGATTTTTTCAGGGAAATAACGTCT CTTCCATCCCACTTGTTAAAACAAAACAAAACGGAAGAGAAGAAATGAGCAAAGCAAACA AACAAACAAACAAAACCCTTCTGGCTTTGTTTGGACCTTCTGTTTCCTGTTTTTCTCAAT TAAACAATTATCAGCCTAAAGAGTTCTGGGTGGTTTGGGATGGGGTGTGTGTGGGTGTGT GTGTGTGTTTATAACATCAAGCAAGGATTTGTTGATGAGGGTGAGGAGCTCGTTGATAAT GATCTGACTATTGCCATTGTTTACTTTCAATCAGAACAGGGAGAAAACCTTCAAAGAGTG TTTAAGGTCTCTACCAATAAATCCCTAGTTAGTGTAAACATTTAATGAGACAGCATTCAG ATTTCTAGTGGCAACATGGTCCAGATTTTGCCAGCCAGAGGAGTAGAAATCAGATCAGTA ACTAGAATCTATTTAGCTAGCCACAGCTAGAAACAGAACATGACCCCCTCCCAAATGACT TGGCTGTTTTTTATTTAGGATCCTAAAATGTAAACTGACTCCACTACCGACCTTGTATCT AGGTAGGTTTCCAGCTTCAAAATGGGATACATACCATGGCAGAACTGGAAGAGACCTCAG AATCACCATAGTGAACCGGCTCAAAACTATAAACAGACACAGGAGAATGGAAGCAACTTG TCAAGAAAAGCACAGCTGTTTAGTAAGGGAGGCAGGGAAGGACACTGTGACTCCAGATGC CTGAAGCACACCTGCATCCTTTCCACCATATCCAGCTGCTTACTTTTATTCTTTTTTTTT TTTTTTAAGGACAAAGGAGAGCATGCTTACTTTTATTTCAAACAGGAACTTACTCAATAT GCCAAAACTTCTTTAAGTCTGCTATCAGTTTCTGTTGTCTTAACTTCCAAATGAACAAAA ATAAAAAGCACTTATGCAAAATATTGTGTTATATTCCATCTCAACCCAGATGCAGGACAA GTACTCCAAAAGTGGCATTGCTTGTTTCTTAAAAGAAGATGACAGTTATTGGGACCCCAA TGACGAAGAGAGTATGAACAGCCCCTGCTGGCAAGTCAAGTGGCAACTCCGTCAGCTCGT TAGAAAGGTAGGTAACCTCACCAGGTGACCTCACCAGCAGGCGGAGAAGGCCAGAAGAAT TCCTTAAAGCAAAGGAATCTTTAAGATAATCAAGTCTAGACTCTTCATTTTACAAATAAG AAAACTTAGGCCCAGAGTATTTAAGTAATTTTCCCCAAATTCATAGAACTAGGAAAATGG GGCATAGCAGCAAAGGGCAGGACCTGGCCGACTCCTGGTCTAGAGTTCATTCCTCTGCCC CGGACAGCCTCCACATCTAGTCTAACCTTTTGATCTCACATTATGGAAACTGAGGCACAC ACAGGGTAATGAAGAGAAGGTCACAAAGTCATAAAGAATGTGTGGCATTGTTTTTCATTC AAAAGATAAAGAAGATCAAATAATGATATTTTATATTCTTCCCACATTGCTGATGTCTGG AATTAAATATTTGTTTTTGTATGCATATAGAGATAAAGAAAGAGGAAAATAAGAGGAAAG AAAGAGGAAAGGAAGGGAAGGGAAGAAAGAGATACTTTGAGAAATTGAAGGTGGTTTTTT CTTAATTTACAGCCAATAAATAACAAATTACAAAAAGTATCTGTTTATGGAAGTTGCTTA AACAGGACCTCCAGCAGAGACATGTTAGTTAACAGTTTATTTTACTAAATGTGGCAGAGT GACAGATCTAATCAAGTTTCTTCTCTTAGGCTCTTCCTTCTTTATAAGATGGCATTAAAT AATATTTGCAGCCGGGTGTAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAG GCAGGCGGATCACCTGAGGTCAGGAGTTGAAGACCAGCCTGGCCAACATGGTGAAACCCT GTGTCTACTAAAAATACAAAAATTAGCAAAGTGTGGTGGTGTGTGCCTGTACTCCCAGCT ACTTGGGAGGCTGAGACAGGAGAACTGCTTGAACCTAAGAGGCAGAAGTTGCAGTGAGCT GAGATCATGCCACTGCACTCTAGCCTGGGCAACAGAGCAAGACTCTATCTCAAAAACCAA AAAAAAAAAAAAATTGCTTCTGCCTATGTGAAAATATCAGATGAGAACACAGCTATAAAA ATACTCTGTAAACTATGAAGTACCACATACACCACCATTGTTTAAAGACGTTAACTGGGG GAATTCCCAGGGTAGGAGGAGAATGTGTTTTACACATGTTTATAAGTCCATTGTTTGGTG TTCTGCATCTGTTTCTCCATATAAATACTGTTATGTTGGTGGTTAGGGATCAAGCTGATA ATCCTGAGCTGTTTTCACAGTAGAGCCCTGACACATGTGAGATGCTATTTCTATGGGAAA TGAAACTAGACTTCCTTCTAGGAGTCCTAGAAACATACCTGTTCTGTGGCTGCCCTGGCG GCATTGCTCCAGACAGGGGGGCCCACTCCACACAAGCTGTACGGAAGCAGCTATGATTCC ACCACTGCAAATGACAGCAAGTGTTCAGGGGGCAAGGACCAGGAGACTAGGAAAAGCCTG GGCTGGAGAAAGGTCCTGAGGAAGCTGAGAAATGAAACTCCCAAGTTCCCGGGATAGGGG CTTGGGGAGGGTGGAGGTGCGATTGTCCAGCAGGGCAGAGAGACTGAGAACTAGGGTGGA AATCTGGAGACTGAGGAGAGGGCTGGGTGCTGTGGACAGGGAGTGGGGAGATAAGAGAAA TAGTGAGGACATTTCTCTTTCCTGCTATTCCTGCCATTCTCCCTCCCATTCTCACATCCT GCTACCAACTAGAATAGCGGGAAGCTGGGAGAGAACACAGAGGGAATAGGTGAGAATGTG GGAAAAATAATTCTCTTTTTCTTTTCAGGCACATTAGTTGAACAGATTTATTCCAGTAAA TATCCTATGCCCATTTCATACATTATCTCATTTAATCCTCACGACAGCTCTGAATAATAA ATCGTTATTATCCTCTTAAATATATTTTAAAAATAGATTAATAAATTGAAGTTTAGATCA GTTAAATAACTTGAACAGTCTCACAGAGCCAGTAACTGAAACATTTGAATGCAGGGCATC TGGCCATGCTTCTAGTCACTCTTTTTATTTTGCCTCCCACATTGTAGGAAAGACCCTTTT CTTTTTCCTGTTGCTTCCCCTTCTTTCCTTCCTTTCTGTTGCAGAATAAGAGAAAGAGAG TAAGAGTGGGAAAGAGAGACACACAGAGAGAAATGAGAGGCAGAGATAAGAGAGAATGCT GTGGTTTCCTCTCACTTCCCCTTCCCGTAAGTCAGTGCCCAGGGAACTGATTACAGTCAG TCCACCGCCACCACTCCCTGCCCCCATTATCCGGCATCAGGGCTTGCGGTGGAGGGAGAA GCAGAGAGCTTCTGCTTTGGGCTGGAAGTACAGAGAAGGCAAGTTTCTGACAGTTGCAAC ATTAACTACAGTGACTGAGAAAGAGGGCAGTGATGGGAGAAGGTGGCAGGAGGGACAGAG CTGAATTCAGAAGCCATGGATGAGCCAAGTCAGGGTCTTCCCATTTAATAGAGAGGTTTG GTTTTCACTCTTTCTTACTGGTTTTCCCCACTGGTTAGTACAAAGGCTGGGGGAGGTTAC TAGATATTTAGCAAAGATATGGGAAGATGGTAAAATATCTTTATGTTGAGAATGGCTCAG CCACATTCTCAGAAGTGAAAGAATGACACGGTGTTGTCAGGTTATACCTCGATAGGCTAT GTATGTCTGTGGGCATCCTGAGAGAGAGGAAGTGTGCCCTGCATCTTGAGGCTTGGGTCT GTCCAATAATTTTAAGCCCCTGGGCTCTGCTACCCAGTGCACTTATACACACACACACAT GAATGTGCACATACATACACCCCACACACAGAAAGTGACATGACATGGCTGCCACACCCA TCAGCCACATTTGGCTGACATCACATGGCGGATGGCTTCTTCCTCCTGCACTGCTCCAGG TGTGGCCTTTCCAAGACTTCATCCAGCAACAGAACTTCCCAGGCAGGGGACCATCCCTTG ATTGCTGTGCTGGGACAGCTATCTCAATATTTATCCCAGCTCCCACCCCACCCCTTACAG ACCCTATGCTTGACCAACTTAAAACTTCCCAGATTGATAATGCATGTAGAAATTTCCTGT TAGACATCAGCAAGATGAGCCATAGGCATTCTATAGTCAGTTTAAATTTTTAGGGAAATT AACAAGCTTTATTCAATAATATTTGCAGATGATTTTGAGAACCTCTGAGGAAACCATTTC TACAGTTCAAGGTAGTATCTTTTTTGTTGTTATTTTAATTTTTTACTGTCATCTTCATGA CAGGTTGTGAATAGTTCTCCATTCTCCTTCTCTGTGTTCTCATCCACTCATCCATCCTCT GATCTGCTGCTCCGTATCTCAAGCCACTTGTTGATTCTACTTCCCTCTTTACATTGGCAG CTAGGAAGCTCAGAACCAAATCTGTGGCCCATCTATGGTCAGAACTTTATTTCAACTTAA TTTTATTCTTCCCCATGAATTTTCCTTTCACCTTAATTTCTTCACTTATTAGTTTCTACC TTCTAATGTGTTACAAAGAAGCCATCTTAAATCGTTTCTGGGAAATTGAGAGAAATAAAT GAAGTCCCTTAAAGTTACCCTTCTTTGTTTCAGGCCACCACTGGGCTCCAGGTCTTTCTT TACAAAAGCCTCCTCCTCCATCATCCTTTTCCCAACAATCTTTCTACCCACCCACGATCC TCATCCTGCGGTCTCCACCTGTGGCCACACCACCCTCTTGTTCATGGTCAGCAGCCTTCT CTCGACCCACCTCTCTGTGCACTACTGTTGCCCAGGCTGGCTTCTTTAGCTTTCCATCTG GCACTCCATCGTACTTTACAGCTCACGTAATTGTCACCTCTTCAGAGAGGGCTTCCCTGG ACACCTTTCTAAGTAAATTCCCTGCACTCTGTTATTTTTATCACATGTACCTTGTTCATT TCCTTTCAGTTATTTTTTTAAATCTGTTATTCTTTTCCAATGCAATAAACTTCTTCATCA CTTGGCACCCCCATTTTCCTTTATTAAATATGTTTTCTTAAATATAAAGGACAGGACCTG TTCCTGGGGTCTAAGCCTTCTTTCTTATCATTTCTCCAAAGGTGAAAGCAGTAGTGAGAA TGTTGAACACTCCACCTATTCAGATGAGGCATACCAGATTAATGGTCTACAGCAGATAGA TGCATGTACTGTTTTCAGTGTTGGAAGAATAAAATTCTTTGTTATTCATCCCAGTAAGGT GAAACACAACTCTGTATACCAAGATATATCCATGGTACCTCGATATACATATTTGCAGGT TTCTTTTTTGGGAGGTGTTTGCTATAACCAGTTGGAAATTTCCTCTTTTAAAAATTTGCT TTCAAATCTAGGCTTTCCTATCCATATCCTTGAAATGACCTTAACAAATCTGTTGCCCAG GCTGGAGTGCAGTGGTACGATCATGGCTCACTGCAGCCTCAACTTCCTGGCCTCAAACAA TCCTCCCACCTCAGCTTCCCGAATAGTAGGACTACGGGCACAGGCCAACACGCCTGGCTG ATTTTTCTATTTTTTATAGAGACAAGGTTTCACTATGTTGCCCAGGCTAATCTCAAACTC TCAGGCTAAGTGATCCACCCATCTTGGCCTCCAAATTGTCACTTTCTAATTCATATTTTC TGTAGAAGGCTGTAAGTCCCTTGAGGACATGGTCAGTGAAATCAGTGATTAATATTTGTA GCCCTCTGGGGTGTAGTGCCTTACCCTAGCACTGTCTGTTTGATGAAAGAATATAATTTA CTTACAACCAATGTAAGCACACTTGGGAAGTTTGAACTGATTCTTTTAGAGAAAGTCATT TGTTACATTTCTTTTTTTTTTTTTTTTTTTTGACGGAGTCTTGCTCTGTTGCCCAGGCTG GAGTGCAATGGTGAGATCTCTGCTCACTGCAAGCTCCGCCTCCTGGATTCACACCATTCT CCTGCCTCAGCCTCCTGAGTAGTTGGGACTATAGGTGCCTGCCACCATGCCCAGCTAATT TTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATAGTCTCAATCTCC TGACCATCTGTTTGTTGGTACCACTCTGTTTATTTCTGTATGTAATTCAAGGTGGAAATT TGCCAATACGTAGTTATTTGCACAATTTAACTCAGCAGGATTATTACACAGCTACAGCTA TTTCTTTATTTATATTTTTGGAAAAGGGATAGAATCTTCACTTTGTTGTATCTTCACTTT GTTTCTCTTTGGACCCTACCCGTGAGACACTAATAAATTATAATCCATGTTACTGCTTAT TCTTTCCGTGTAAAGTACTTTTCAAGTTGATCATAAGCTGAGGTAGGTTGATCATAATAT CAAAATGTTATTTTTATGAAAACTCATAGAATCAACTTTGGAAGCCCAGTATGCTTACGA TGGCTGATTGACAACACCTATGAAGAGCAAGGTATTGGAGAACTAGTTTGGCAAGTGTTG ATGACCCTTTATCATTTCTCTTTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGA AAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATT GTCTTCTCCAAGTAAGAGAAACAACAAATAAGTGACTTAAGGGAAAATAATGGAAGGATT GTGCCAAGTAACTTATTTTTTAAAGAATTTTATCTGAAATGTTTATATGGCTATCTACAA AATGCTCAGTATTAATCAGATCTCAGATTGACTGTTTTCAGATGCAAGATTACAGACAAA CAGCTCAATTATTGCCACGACATAACTGGCCTCAGGAAAATTACAAAGTGGGAGAATTTT GTCTTTGCAGTTTTCAGGATCCCATTTTTTTTCCTTCTTTAGAGTAATTTCTCGCTCTTT CTTTCTTTCTTTTTCTTTCTTTCTTTCCTTTTTTTTTTTAGACAGAGTTTCACGTTTGTT GCCCAGGCTGGAGTGCAATGGCACCATCTCGGCTCACTGCAACCTCCGCCTCCAGTGTTC AAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACGCAGCTCCACGC CTGGCTAATTTTGTATTTTTAGTAGAGATGGGATTTCTCCATGTTGGTCAGGCTGGTCTC GAACTCCCGACCTCAGGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGT GTGAGCCACTGCACCCAGCCTTTCTCTCTTATGATTACTTCTTCCATCCCTCTGCACTTC TCTTCTTTGCTCGCCATCAAATCTCCCTTCTCTTTAAAGGTTCTAAATCATTTACTATCC CTATGAATCACTAGGTGCTCCTAGTGGCATTTACATTAAATTAAACCACAGGAGATTGCC AATATTTGACCATATTTTACTTACACAAATGTCAGTTTCATATAGTTTAACCATATATGT TACATCTAATTTATATATAGGCAGAACATGTGTCGATATGTTGCTATGTAATACTGTGCA TGGGTATTTTTTTGTTTTTTTTTTGTTTTTTTGAGACGGAGTTTCACTTTTGTCGCCCAG GCTGGAGTGCAATGGTGCCATCTCGGCTCACTGCAACCTTTGCCTCCCAGGTTCAAGCGA TTCTCCTGCCTCAGCTTCCCGAGTAGCTGGGATTACAAGCATGCACCACTACACGAGGCT GGTCTCAAACTCTTGACCTCAGCTGATCCACACCCCCCCGGCCTCCCAAAGTGCTGGAAT TACAGGCGTGAGCCACCACACCAGGCCTCTGTGCATGGGTCTTATAGTGTAAATATCTAG GTTGGAATCACAGCTCCTCTTCACCTAGATGCATGTTTTGAGCTAATTACTTAACCTAGT CAAGCTTCAGTTTCTTCATATGCAAAGATGAGACAAATCTTAACCCACAAAATGATGCAA AATGTCTGGTCTATTGTATGTCCTCAAGAAATACTCACCTTTATTTTTGTCAGAGGCTTT ATCCCGTAAATTTGTCTAAAAATATTTCAGACATCAGTTAATAGATAAAAAGTTTGTTTG GGGGTTTGGGGTTGGTTGGTTGGTTTAGTTTCTTCTGGGTAGTTGCCTTCTTGACATTCT TGGACTCATGTTTTATAAATGATTGTCATGTTCTGCCTACAAGTGAGGGGATTATTATGA TGTTACTGCTTGCTACTCATCAATAAATATAACTGGTTTACGCTCTGGAAAAGCCCAATT TTGCACCAATCGTGGAGATAGGCTAAAAGTGTAAATGAATATCATTTTGGAAGGTTCATT TTTCATTCAAAACCTTTGAGTGTGAAAGATTCAAGGATCTGAGGATCTTTAAATCTAGGC TCCTTTGCCAACTTTGTGCCTCTATTATTTTTGGCTAGAGACGCCATCTGCTTGGATGTG CCTTTGACTCTGGAGAGCTGAGAAAGATCAAGGGGGGACCCAAAGAGTCCAAAAGGAATG GCAAGAACTTCTGAGATTTAGGCCTAAAGAAATAGATACGTTTATTTCGGTTTCCTTCTG GATTGTCCACTTAAGTTCACCAGCACAAGACGGGAGGAACAGATTCAGGGCAGAAGTTCT GCCCAGGAGAAACCATTGCTATCTGAGTGGGCCATCCCTTGTGCTACCATTCTAAGTGTG ACACATGTGGCATAAGCAGCTGACAAGGTATAAAAAGACAAGGGACTCCCAACAGTTCCC AATGTCACAATGATGCAGGAACCTCCCAATTTCTATGTGACTAGAATTTATAATCCACAT TAAGATTGAAGGAGGAAGAAGTTTGATATTAGATTGAAATCCCTGGCAAGCCCAACAAAA ATATAGGCTGGCCACAGCTGCAAAAAAGCTCCTTGCTTTGCTACAAATTCCCTTCTGTTA ACGCTCTTTCTCTCTAAATTTCCTACAGACTCCAAGAATGAAAAGGCTCTGGGCCGCAAA ATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGG AATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTT CGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATT TACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGT TGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTT AAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCAT GAAGCCAGTTTTTTTGGGGCCTTTTTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAATA ACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAAAAATCT GACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAG CAGCCACAACCAAAAAATTCTACAACACACACTGTTCTGAAAGTGACTCACTTATCCCAA GAGAATGAAATTGCTGAAAGATCTTTCAGGACTCTACCTCATATCAGTTTGCTAGCAGAA ATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCTGTCTTTATA ATCTACTCCTTGTAAAGACTGTAGAAGAAAGAGCAACAATCCATCTCTCAAGTAGTGTAT CACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAGAAGA GGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACAT TTTGGGAACCCAAGGTGGGTAGATCACGAGATCAAGAGATCAAGACCATAGTGACCAACA TAGTGAAACCCCATCTCTACTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCACATGCCT GTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGGAGGCAGAGG TTGCAGTGTGGTGAGATCATGCCACTACACTCCAGCCTGGCGACAGAGCGAGACTTGGTT TCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTCAATAAAATTCT ATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGTTTTAGTACT CACTTGTTTCATAATATCAAGATTACTAAAAATGGGGGAAAAGACTTCTAATCTTTTTTT CATAATATCTTTGACACATATTACAGAAGAAATAAATTTCTTACTTTTAATTTAATATGA OMIM ID 603598