| Entrez gene ID | | 8744 |
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| Official gene symbol | | TNFSF9 |
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| Full name | | tumor necrosis factor (ligand) superfamily, member 9 |
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| Aliases | | ,4-1BB-L,CD137L, |
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| Gene summary | | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. |
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| Location | | Chromosome: 19 Locus: 19p13.3 |
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| Gene position | | 6531010 - 6535939 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 4930 bp |
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| Gene sequence |
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| OMIM ID | | 606182 |
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