Entrez gene ID | | 89832 |
Official gene symbol | | CHRFAM7A |
Full name | | CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion |
Aliases | | ,CHRNA7,CHRNA7-DR1,D-10,MGC120482,MGC120483, |
Gene summary | | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq] |
Location | | Chromosome: 15 Locus: 15q13.1 |
Gene position | | 30685864 - 30653443 Map Viewer |
Gene orientation | | minus |
Gene size | | 32422 bp |
Gene sequence |
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OMIM ID | | 609756 |
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