Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CCNE2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9134
Official gene symbolCCNE2
Full namecyclin E2
Aliases,CYCE2,
Gene summaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq]
LocationChromosome: 8   Locus: 8q22.1
Gene position95907482 - 95892452  Map Viewer
Gene orientationminus
Gene size15031 bp
Gene sequence
OMIM ID603775