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Gene information for CD8B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID926
Official gene symbolCD8B
Full nameCD8b molecule
Aliases,CD8B1,LEU2,LY3,LYT3,MGC119115,P37,
Gene summaryThe CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq]
LocationChromosome: 2   Locus: 2p12
Gene position87089047 - 87042460  Map Viewer
Gene orientationminus
Gene size46588 bp
Gene sequence
OMIM ID186730