Entrez gene ID | | 939 |
Official gene symbol | | CD27 |
Full name | | CD27 molecule |
Aliases | | ,MGC20393,S152,T14,TNFRSF7,Tp55, |
Gene summary | | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12p13 |
Gene position | | 6554051 - 6560884 Map Viewer |
Gene orientation | | plus |
Gene size | | 6834 bp |
Gene sequence |
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OMIM ID | | 186711 |
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