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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for OPN4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID94233
Official gene symbolOPN4
Full nameopsin 4
Aliases,MGC142118,MOP,
Gene summaryOpsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q22
Gene position88414314 - 88426217  Map Viewer
Gene orientationplus
Gene size11904 bp
Gene sequence
OMIM ID606665