Entrez gene ID | | 9439 |
Official gene symbol | | MED23 |
Full name | | mediator complex subunit 23 |
Aliases | | ,ARC130,CRSP130,CRSP133,CRSP3,DKFZp434H0117,DRIP130,SUR-2,SUR2, |
Gene summary | | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6q22.33-q24.1 |
Gene position | | 131949363 - 131895106 Map Viewer |
Gene orientation | | minus |
Gene size | | 54258 bp |
Gene sequence |
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OMIM ID | | 605042 |
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