Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BAG4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9530
Official gene symbolBAG4
Full nameBCL2-associated athanogene 4
Aliases,BAG-4,SODD,
Gene summaryThe protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq]
LocationChromosome: 8   Locus: 8p11.23
Gene position38034106 - 38068537  Map Viewer
Gene orientationplus
Gene size34432 bp
Gene sequence
OMIM ID603884