Entrez gene ID | | 9604 |
Official gene symbol | | RNF14 |
Full name | | ring finger protein 14 |
Aliases | | ,ARA54,FLJ26004,HFB30,HRIHFB2038,TRIAD2, |
Gene summary | | The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q23.3-q31.1 |
Gene position | | 141346437 - 141368754 Map Viewer |
Gene orientation | | plus |
Gene size | | 22318 bp |
Gene sequence |
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OMIM ID | | 605675 |