Entrez gene ID | | 9757 |
Official gene symbol | | KMT2B |
Full name | | myeloid/lymphoid or mixed-lineage leukemia 4 |
Aliases | | ,HRX2,MLL1B,MLL2,MLL4,TRX2,WBP7, |
Gene summary | | This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19q13.1 |
Gene position | | 36208921 - 36229779 Map Viewer |
Gene orientation | | plus |
Gene size | | 20859 bp |
Gene sequence |
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OMIM ID | | 606834 |
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