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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RAPGEF5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9771
Official gene symbolRAPGEF5
Full nameRap guanine nucleotide exchange factor (GEF) 5
Aliases,GFR,KIAA0277,MR-GEF,REPAC,
Gene summaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM]
LocationChromosome: 7   Locus: 7p15.3
Gene position22396533 - 22157908  Map Viewer
Gene orientationminus
Gene size238626 bp
Gene sequence
OMIM ID609527