Entrez gene ID | | 9771 |
Official gene symbol | | RAPGEF5 |
Full name | | Rap guanine nucleotide exchange factor (GEF) 5 |
Aliases | | ,GFR,KIAA0277,MR-GEF,REPAC, |
Gene summary | | Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM] |
Location | | Chromosome: 7 Locus: 7p15.3 |
Gene position | | 22396533 - 22157908 Map Viewer |
Gene orientation | | minus |
Gene size | | 238626 bp |
Gene sequence |
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OMIM ID | | 609527 |