Entrez gene ID | | 9966 |
Official gene symbol | | TNFSF15 |
Full name | | tumor necrosis factor (ligand) superfamily, member 15 |
Aliases | | ,MGC129934,MGC129935,TL1,TL1A,VEGI,VEGI192A, |
Gene summary | | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q32 |
Gene position | | 117568408 - 117551600 Map Viewer |
Gene orientation | | minus |
Gene size | | 16809 bp |
Gene sequence |
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OMIM ID | | 604052 |
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