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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CDK6 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000080 G1 phase of mitotic cell cycle IEP GO:0000080 G1 phase of mitotic cell cycle TAS GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000278 mitotic cell cycle TAS GO:0001954 positive regulation of cell-matrix adhesion IDA GO:0003323 type B pancreatic cell development IDA GO:0006468 protein phosphorylation IDA GO:0007049 cell cycle IDA GO:0007050 cell cycle arrest TAS GO:0008285 negative regulation of cell proliferation TAS GO:0009615 response to virus IEP GO:0010468 regulation of gene expression IDA GO:0010468 regulation of gene expression IMP GO:0014002 astrocyte development ISS GO:0021542 dentate gyrus development ISS GO:0021670 lateral ventricle development ISS GO:0030097 hemopoiesis IEA GO:0042063 gliogenesis IMP GO:0043697 cell dedifferentiation IMP GO:0045596 negative regulation of cell differentiation TAS GO:0045638 negative regulation of myeloid cell differentiation IDA GO:0045646 regulation of erythrocyte differentiation IMP GO:0045668 negative regulation of osteoblast differentiation IDA GO:0045786 negative regulation of cell cycle IDA GO:0048146 positive regulation of fibroblast proliferation IMP GO:0048699 generation of neurons ISS GO:0050680 negative regulation of epithelial cell proliferation IMP GO:0051301 cell division IEA GO:2000145 regulation of cell motility ISS GO:2000773 negative regulation of cellular senescence IDA cellular_component GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA GO:0001726 ruffle IDA GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS molecular_function GO:0000166 nucleotide binding IEA GO:0004693 cyclin-dependent protein kinase activity IDA GO:0005515 protein binding IPI GO:0005524 ATP binding IDA GO:0030332 cyclin binding IPI

Protein-protein interaction details for CDK6 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CDKN2C Affinity Capture-MS physical 17353931 CDKN2A Protein-peptide physical 8805225 CCND1 Reconstituted Complex physical 10580009 CDKN2D Co-crystal Structure physical 9751051 PPP2CA Co-purification physical 10934208 PPP2CA Biochemical Activity physical 10934208 PPM1B Biochemical Activity physical 10934208 PPM1B Co-purification physical 10934208 CDK2 Co-purification physical 10934208 CCND1 Affinity Capture-Western physical 11360184 CCND2 Affinity Capture-Western physical 11360184 CCND3 Affinity Capture-Western physical 11360184 CDKN1B Affinity Capture-Western physical 11360184 CDKN2A Co-crystal Structure physical 9751050 CDKN2C Affinity Capture-Western physical 8001816 CDKN2C Reconstituted Complex physical 8001816 CDKN2C Two-hybrid physical 8001816 CDKN2C Co-crystal Structure physical 11124804 CDKN2A Reconstituted Complex physical 11739795 CDC37 Reconstituted Complex physical 8666233 CCND3 Affinity Capture-Western physical 8114739 FBXO7 Affinity Capture-Western physical 18495667 CDKN1A Affinity Capture-Western physical 20102411 UHRF2 Far Western physical 21952639 CDKN2A Affinity Capture-MS physical 17955473 UBC Co-purification physical 17623298