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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for LRRK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade IDA GO:0000186 activation of MAPKK activity IDA GO:0001934 positive regulation of protein phosphorylation IMP GO:0006979 response to oxidative stress IMP GO:0007264 small GTPase mediated signal transduction IEA GO:0007406 negative regulation of neuroblast proliferation IMP GO:0007528 neuromuscular junction development IMP GO:0008340 determination of adult lifespan IMP GO:0010508 positive regulation of autophagy ISS GO:0010942 positive regulation of cell death IMP GO:0014043 negative regulation of neuron maturation IMP GO:0018105 peptidyl-serine phosphorylation IDA GO:0021772 olfactory bulb development IMP GO:0022028 tangential migration from the subventricular zone to the olfactory bulb IMP GO:0031398 positive regulation of protein ubiquitination IDA GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS GO:0035564 regulation of kidney size ISS GO:0035640 exploration behavior IMP GO:0040012 regulation of locomotion IMP GO:0042391 regulation of membrane potential IMP GO:0043068 positive regulation of programmed cell death IDA GO:0043547 positive regulation of GTPase activity IDA GO:0046777 protein autophosphorylation IDA GO:0046777 protein autophosphorylation IMP GO:0048312 intracellular distribution of mitochondria IMP GO:0060161 positive regulation of dopamine receptor signaling pathway IMP GO:0061002 negative regulation of dendritic spine morphogenesis IMP GO:0070997 neuron death IMP GO:2000173 negative regulation of branching morphogenesis of a nerve IMP cellular_component GO:0005622 intracellular IMP GO:0005624 membrane fraction IDA GO:0005737 cytoplasm IDA GO:0005802 trans-Golgi network IEA GO:0005886 plasma membrane IEA GO:0008021 synaptic vesicle IEA GO:0032473 external side of mitochondrial outer membrane IDA GO:0045121 membrane raft IEA molecular_function GO:0000166 nucleotide binding IEA GO:0003924 GTPase activity IDA GO:0004672 protein kinase activity IDA GO:0004674 protein serine/threonine kinase activity IDA GO:0004708 MAP kinase kinase activity IDA GO:0005096 GTPase activator activity IDA GO:0005488 binding IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0005525 GTP binding IDA GO:0015631 tubulin binding IDA GO:0034211 GTP-dependent protein kinase activity IDA GO:0034211 GTP-dependent protein kinase activity IMP GO:0042803 protein homodimerization activity IPI

Protein-protein interaction details for LRRK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PARK2 Affinity Capture-Western physical 16352719 PARK2 Affinity Capture-Western physical 16352719 SNCA Affinity Capture-Western physical 19878656 SNCA Affinity Capture-Western physical 19878656 STUB1 Affinity Capture-Western physical 19196961 STUB1 Affinity Capture-Western physical 19196961 STUB1 Affinity Capture-Western physical 19536328 STUB1 Affinity Capture-Western physical 19536328 HSP90AA1 Affinity Capture-Western physical 19536328 HSP90AA1 Affinity Capture-Western physical 19536328 UBC Affinity Capture-Western physical 19536328