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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PTK2B (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000165 MAPKKK cascade IEA GO:0001525 angiogenesis IEA GO:0001556 oocyte maturation IEA GO:0001666 response to hypoxia IEA GO:0006461 protein complex assembly TAS GO:0006468 protein phosphorylation TAS GO:0006915 apoptosis TAS GO:0006950 response to stress TAS GO:0006970 response to osmotic stress IEA GO:0007015 actin filament organization IEA GO:0007155 cell adhesion IEA GO:0007165 signal transduction NAS GO:0007172 signal complex assembly IEA GO:0007173 epidermal growth factor receptor signaling pathway IEA GO:0007204 elevation of cytosolic calcium ion concentration IEA GO:0008284 positive regulation of cell proliferation IEA GO:0009612 response to mechanical stimulus IEA GO:0009725 response to hormone stimulus IEA GO:0009749 response to glucose stimulus IEA GO:0010226 response to lithium ion IEA GO:0010243 response to organic nitrogen IEA GO:0010976 positive regulation of neuron projection development IMP GO:0014009 glial cell proliferation IEA GO:0030154 cell differentiation IEA GO:0030279 negative regulation of ossification IEA GO:0030307 positive regulation of cell growth IEA GO:0030335 positive regulation of cell migration IEA GO:0031175 neuron projection development IEA GO:0032863 activation of Rac GTPase activity IEA GO:0034329 cell junction assembly TAS GO:0042220 response to cocaine IEA GO:0042493 response to drug IEA GO:0042542 response to hydrogen peroxide IEA GO:0042976 activation of Janus kinase activity IEA GO:0043149 stress fiber assembly IEA GO:0043507 positive regulation of JUN kinase activity IEA GO:0043534 blood vessel endothelial cell migration IEA GO:0045453 bone resorption ISS GO:0045471 response to ethanol IEA GO:0045727 positive regulation of translation IEA GO:0045768 positive regulation of anti-apoptosis IEA GO:0048010 vascular endothelial growth factor receptor signaling pathway IMP GO:0048041 focal adhesion assembly IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA GO:0051591 response to cAMP IEA GO:0051592 response to calcium ion IEA GO:0071300 cellular response to retinoic acid IMP GO:2000379 positive regulation of reactive oxygen species metabolic process IEA cellular_component GO:0005634 nucleus IEA GO:0005737 cytoplasm IEA GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005886 plasma membrane IEA GO:0005925 focal adhesion IEA GO:0005938 cell cortex IEA GO:0014069 postsynaptic density IEA GO:0030424 axon IEA GO:0030426 growth cone IEA GO:0045121 membrane raft IEA GO:0048471 perinuclear region of cytoplasm IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004713 protein tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA GO:0004871 signal transducer activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0043423 3-phosphoinositide-dependent protein kinase binding IEA

Protein-protein interaction details for PTK2B (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TGFB1I1 Two-hybrid physical 9422762 TGFB1I1 Two-hybrid physical 11856738 TGFB1I1 Reconstituted Complex physical 11856738 TGFB1I1 Two-hybrid physical 11856738 TGFB1I1 Affinity Capture-Western physical 11856738 CBL Affinity Capture-Western physical 15128873 CBL Affinity Capture-Western physical 15128873 SORBS2 Affinity Capture-Western physical 15128873 SORBS1 Affinity Capture-Western physical 15128873 CD2AP Affinity Capture-Western physical 15128873 SORBS2 Reconstituted Complex physical 15128873 GIT1 Affinity Capture-Western physical 12629171 GSN Two-hybrid physical 12578912 GSN Affinity Capture-Western physical 12578912 GSN Biochemical Activity physical 12578912 GRIN2A Affinity Capture-Western physical 12576483 DLG3 Affinity Capture-Western physical 12576483 DLG4 Affinity Capture-Western physical 12576483 DLG3 Affinity Capture-Western physical 12576483 DLG4 Reconstituted Complex physical 12576483 DLG3 Reconstituted Complex physical 12576483 PTPN6 Affinity Capture-Western physical 10747947 PTPN6 Affinity Capture-Western physical 10747947 SYK Affinity Capture-Western physical 10747947 LCK Affinity Capture-Western physical 9091579 FYN Affinity Capture-Western physical 9091579 PTK2B Biochemical Activity physical 9512511 JAK3 Affinity Capture-Western physical 9512511 JAK1 Affinity Capture-Western physical 10702271 IL7R Affinity Capture-Western physical 10702271 PXN Affinity Capture-Western physical 9099734 PXN Far Western physical 9099734 KCNA2 Affinity Capture-Western physical 11739373 TGFB1I1 Reconstituted Complex physical 9422762 PXN Reconstituted Complex physical 9422762 PXN Affinity Capture-Western physical 9422762 TGFB1I1 Affinity Capture-Western physical 9422762 LYN Affinity Capture-Western physical 11311138 BCAR1 Affinity Capture-Western physical 9020138 NEDD9 Affinity Capture-Western physical 9020138 JAK2 Affinity Capture-Western physical 11818507 EGFR Affinity Capture-Western physical 10777553 SRC Affinity Capture-Western physical 10777553 TGFB1I1 Reconstituted Complex physical 9858471 BCAR1 Affinity Capture-Western physical 11036077 PXN Affinity Capture-Western physical 11036077 PITPNM3 Two-hybrid physical 10022914 PITPNM1 Two-hybrid physical 10022914 PITPNM2 Two-hybrid physical 10022914 PITPNM3 Reconstituted Complex physical 10022914 PITPNM3 Affinity Capture-Western physical 10022914 PITPNM1 Affinity Capture-Western physical 10022914 PITPNM2 Affinity Capture-Western physical 10022914 BCAR1 Affinity Capture-Western physical 8995252 SLC2A1 Affinity Capture-Western physical 11007796 PRKCD Affinity Capture-Western physical 11352632 ASAP2 Reconstituted Complex physical 10022920 ASAP2 Affinity Capture-Western physical 10022920 GNA13 Affinity Capture-Western physical 10821841 LPXN Affinity Capture-Western physical 9565592 ITGB2 Affinity Capture-Western physical 10961871 TLN1 Affinity Capture-Western physical 9442086 NPHP1 Affinity Capture-Western physical 11493697 NPHP1 Reconstituted Complex physical 11493697 PTPN12 Biochemical Activity physical 11337490 ITGB3 Reconstituted Complex physical 11683411 PTPN11 Affinity Capture-Western physical 10880513 PTPN11 Affinity Capture-Western physical 10880513 PTPN11 Far Western physical 10880513 PTPN11 Biochemical Activity physical 10880513 PTPN6 Affinity Capture-Western physical 10521452 PTPN6 Affinity Capture-Western physical 10521452 PTPN6 Biochemical Activity physical 10521452 SRC Reconstituted Complex physical 10521452 GRB2 Affinity Capture-Western physical 10329689 RB1CC1 Affinity Capture-Western physical 10769033 RB1CC1 Reconstituted Complex physical 10769033 RB1CC1 Two-hybrid physical 10769033 RB1CC1 Phenotypic Suppression genetic 10769033 CBL Affinity Capture-Western physical 11149930 EWSR1 Affinity Capture-Western physical 10322114 EWSR1 Reconstituted Complex physical 10322114 SRC Affinity Capture-Western physical 8849729 SRC Reconstituted Complex physical 8849729 VAV1 Reconstituted Complex physical 10867021 FYN Reconstituted Complex physical 10867021 FYN Biochemical Activity physical 9104812 FYN Affinity Capture-Western physical 9104812 GRIN2A Affinity Capture-Western physical 11478920 RASA1 Affinity Capture-Western physical 10708762 RASA1 Reconstituted Complex physical 10708762 ERBB2 Affinity Capture-Western physical 10713673 RASA1 Affinity Capture-Western physical 10713673 SOCS3 Two-hybrid physical 9344848 DCC Reconstituted Complex physical 15494733 MBD2 Two-hybrid physical 19661918 MBD2 Reconstituted Complex physical 19661918 MBD2 Affinity Capture-Western physical 19661918 PTEN Affinity Capture-MS physical 15717329 SOCS2 Two-hybrid physical 20543098 SOCS2 Affinity Capture-Western physical 20543098 SOCS2 Affinity Capture-Western physical 20543098 UBC Affinity Capture-Western physical 20543098