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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for LAT (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006954 inflammatory response IEA GO:0006955 immune response IDA GO:0007165 signal transduction IEA GO:0007229 integrin-mediated signaling pathway IDA GO:0007265 Ras protein signal transduction IMP GO:0007596 blood coagulation TAS GO:0010467 gene expression IEA GO:0019722 calcium-mediated signaling IMP GO:0030168 platelet activation TAS GO:0035556 intracellular signal transduction IDA GO:0042110 T cell activation TAS GO:0043303 mast cell degranulation IEA GO:0050852 T cell receptor signaling pathway TAS GO:0050863 regulation of T cell activation IMP cellular_component GO:0001772 immunological synapse IDA GO:0001772 immunological synapse IEA GO:0005622 intracellular IDA GO:0005886 plasma membrane TAS GO:0016020 membrane IEA GO:0016021 integral to membrane IDA GO:0045121 membrane raft TAS molecular_function GO:0005070 SH3/SH2 adaptor activity IDA GO:0005515 protein binding IPI GO:0019901 protein kinase binding IPI

Protein-protein interaction details for LAT (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID SLA Affinity Capture-Western physical 10449770 SH3BP2 Reconstituted Complex physical 9846481 SH3BP2 Affinity Capture-Western physical 11390470 SHB Affinity Capture-Western physical 10488157 PLCG1 Co-fractionation physical 9729044 SHB Affinity Capture-Western physical 12084069 ITK Affinity Capture-Western physical 10506192 ZAP70 Biochemical Activity physical 11368773 SYK Biochemical Activity physical 11368773 GRB2 Affinity Capture-Western physical 11368773 PLCG1 Affinity Capture-Western physical 11368773 PIK3R1 Affinity Capture-Western physical 11368773 CLYBL Affinity Capture-Western physical 11368773 VAV1 Reconstituted Complex physical 11368773 PIK3R1 Reconstituted Complex physical 11368773 PLCG1 Reconstituted Complex physical 11368773 GAB2 Affinity Capture-Western physical 11572860 PTPRJ Biochemical Activity physical 11259588 GRB2 Affinity Capture-Western physical 9489702 GRAP Affinity Capture-Western physical 9489702 PLCG1 Affinity Capture-Western physical 9489702 GRAP2 Affinity Capture-Western physical 10021361 GRAP2 Reconstituted Complex physical 10021361 GRAP2 Affinity Capture-Western physical 10021361 GRAP2 Affinity Capture-Western physical 10224278 ZAP70 Biochemical Activity physical 12186560 ITK Biochemical Activity physical 12186560 GRAP Reconstituted Complex physical 12186560 GRB2 Reconstituted Complex physical 12186560 VAV1 Reconstituted Complex physical 12186560 VAV1 Affinity Capture-Western physical 12186560 MAP4K1 Affinity Capture-Western physical 11279207 MAP4K1 Co-fractionation physical 11279207 FCGR1A Affinity Capture-Western physical 10781611 FCGR2A Affinity Capture-Western physical 10781611 UBC Affinity Capture-Western physical 17938199 USP19 Affinity Capture-MS physical 19615732 UBC Affinity Capture-Western physical 21282648