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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for GLI3 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0001656 metanephros development IEA GO:0001658 branching involved in ureteric bud morphogenesis IEA GO:0001701 in utero embryonic development IEA GO:0002052 positive regulation of neuroblast proliferation IEA GO:0006351 transcription, DNA-dependent IDA GO:0007411 axon guidance IEA GO:0007442 hindgut morphogenesis IEA GO:0007507 heart development IEA GO:0008285 negative regulation of cell proliferation IEA GO:0009952 anterior/posterior pattern specification IEA GO:0009954 proximal/distal pattern formation IEA GO:0016485 protein processing IEA GO:0021513 spinal cord dorsal/ventral patterning IEA GO:0021543 pallium development IEA GO:0021544 subpallium development IEA GO:0021631 optic nerve morphogenesis IEA GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification IEA GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification IEA GO:0021798 forebrain dorsal/ventral pattern formation IEA GO:0021801 cerebral cortex radial glia guided migration IEA GO:0021861 forebrain radial glial cell differentiation IEA GO:0021915 neural tube development IEA GO:0022018 lateral ganglionic eminence cell proliferation IEA GO:0030318 melanocyte differentiation IEA GO:0030324 lung development IEA GO:0030879 mammary gland development IEA GO:0032332 positive regulation of chondrocyte differentiation IEA GO:0033077 T cell differentiation in thymus IEA GO:0033077 T cell differentiation in thymus ISS GO:0035108 limb morphogenesis IMP GO:0035295 tube development IEA GO:0042307 positive regulation of protein import into nucleus IEA GO:0042475 odontogenesis of dentine-containing tooth IEA GO:0042733 embryonic digit morphogenesis IEA GO:0043066 negative regulation of apoptosis IEA GO:0043586 tongue development IEA GO:0045060 negative thymic T cell selection ISS GO:0045665 negative regulation of neuron differentiation IEA GO:0045669 positive regulation of osteoblast differentiation IEA GO:0045879 negative regulation of smoothened signaling pathway ISS GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045892 negative regulation of transcription, DNA-dependent IEA GO:0045893 positive regulation of transcription, DNA-dependent IEA GO:0045893 positive regulation of transcription, DNA-dependent ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP GO:0046638 positive regulation of alpha-beta T cell differentiation ISS GO:0046639 negative regulation of alpha-beta T cell differentiation ISS GO:0048557 embryonic digestive tract morphogenesis IEA GO:0048589 developmental growth IEA GO:0048593 camera-type eye morphogenesis IEA GO:0048646 anatomical structure formation involved in morphogenesis IEA GO:0048663 neuron fate commitment IEA GO:0048704 embryonic skeletal system morphogenesis IEA GO:0048709 oligodendrocyte differentiation IEA GO:0048839 inner ear development IEA GO:0060021 palate development IEA GO:0060364 frontal suture morphogenesis IEA GO:0060366 lambdoid suture morphogenesis IEA GO:0060367 sagittal suture morphogenesis IEA GO:0060594 mammary gland specification IEA GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning IEA GO:0060840 artery development IEA GO:0060873 anterior semicircular canal development IEA GO:0060875 lateral semicircular canal development IEA GO:0061005 cell differentiation involved in kidney development IEA GO:0070242 thymocyte apoptosis ISS GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IDA cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol IDA GO:0005929 cilium IDA GO:0016592 mediator complex IDA GO:0017053 transcriptional repressor complex IEA GO:0043231 intracellular membrane-bounded organelle IDA molecular_function GO:0003682 chromatin binding IEA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0005515 protein binding IPI GO:0008013 beta-catenin binding IPI GO:0008270 zinc ion binding IEA GO:0035035 histone acetyltransferase binding IPI GO:0042826 histone deacetylase binding IDA GO:0043565 sequence-specific DNA binding IEA GO:0046872 metal ion binding IEA

Protein-protein interaction details for GLI3 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CREBBP Reconstituted Complex physical 10075717 CREBBP Affinity Capture-Western physical 10075717 SUFU Reconstituted Complex physical 10564661 ZIC1 Affinity Capture-Western physical 11238441 ZIC2 Affinity Capture-Western physical 11238441 ZIC1 Reconstituted Complex physical 11238441 ZIC1 Reconstituted Complex physical 11238441 ZIC2 Reconstituted Complex physical 11238441 ZIC3 Reconstituted Complex physical 11238441 STK36 Affinity Capture-Western physical 10806483 SAP18 Phenotypic Enhancement genetic 11960000 MED12 Two-hybrid physical 17000779 MED12 Reconstituted Complex physical 17000779 CREBBP Affinity Capture-Western physical 17000779 BTRC Affinity Capture-Western physical 16705181 SKI Two-hybrid physical 12435627 SKI Reconstituted Complex physical 12435627 SKI Affinity Capture-Western physical 12435627 HDAC1 Affinity Capture-Western physical 12435627