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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for IGF1R (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006916 anti-apoptosis TAS GO:0006955 immune response IMP GO:0007165 signal transduction TAS GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA GO:0007409 axonogenesis IEA GO:0007420 brain development IEA GO:0008284 positive regulation of cell proliferation TAS GO:0008286 insulin receptor signaling pathway TAS GO:0009887 organ morphogenesis IEA GO:0014065 phosphatidylinositol 3-kinase cascade IC GO:0030010 establishment of cell polarity IEA GO:0030238 male sex determination IEA GO:0030335 positive regulation of cell migration IMP GO:0030879 mammary gland development IEA GO:0031017 exocrine pancreas development IEA GO:0031175 neuron projection development IEA GO:0032467 positive regulation of cytokinesis IEA GO:0033197 response to vitamin E IEA GO:0043409 negative regulation of MAPKKK cascade IEA GO:0043410 positive regulation of MAPKKK cascade IEA GO:0045740 positive regulation of DNA replication IMP GO:0045768 positive regulation of anti-apoptosis IEA GO:0046777 protein autophosphorylation IDA GO:0046777 protein autophosphorylation IEA GO:0048009 insulin-like growth factor receptor signaling pathway IDA GO:0048009 insulin-like growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling IDA GO:0051262 protein tetramerization IDA GO:0051291 protein heterooligomerization IEA GO:0051897 positive regulation of protein kinase B signaling cascade IEA GO:0051898 negative regulation of protein kinase B signaling cascade IEA GO:0060740 prostate gland epithelium morphogenesis IEA GO:0090031 positive regulation of steroid hormone biosynthetic process IEA cellular_component GO:0005792 microsome IDA GO:0005886 plasma membrane IEA GO:0005887 integral to plasma membrane IC GO:0005901 caveola IEA GO:0016020 membrane IDA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA GO:0043005 neuron projection IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004713 protein tyrosine kinase activity IDA GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA GO:0004872 receptor activity IEA GO:0005010 insulin-like growth factor-activated receptor activity IDA GO:0005158 insulin receptor binding IDA GO:0005515 protein binding IPI GO:0005520 insulin-like growth factor binding IDA GO:0005524 ATP binding IEA GO:0031994 insulin-like growth factor I binding IPI GO:0042802 identical protein binding IPI GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0043548 phosphatidylinositol 3-kinase binding IPI GO:0043559 insulin binding IPI GO:0043560 insulin receptor substrate binding IEA GO:0043560 insulin receptor substrate binding IPI GO:0046872 metal ion binding IEA

Protein-protein interaction details for IGF1R (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID CSK Two-hybrid physical 10026153 IRS1 Two-hybrid physical 7559507 YWHAE Two-hybrid physical 9111084 SOCS1 Two-hybrid physical 9727029 YWHAG Affinity Capture-MS physical 17353931 GRB10 Affinity Capture-Western physical 12697834 GRB10 Affinity Capture-Western physical 12697834 NEDD4 Affinity Capture-Western physical 12697834 IGF1 Reconstituted Complex physical 1852007 EHD1 Reconstituted Complex physical 11423532 EHD1 Reconstituted Complex physical 11423532 SNAP29 Affinity Capture-Western physical 11423532 IGFBP3 Co-purification physical 9389554 ARHGEF12 Two-hybrid physical 11724822 ARHGEF12 Reconstituted Complex physical 11724822 ARHGEF12 Affinity Capture-Western physical 11724822 JAK1 Reconstituted Complex physical 9492017 PIK3R3 Reconstituted Complex physical 9415396 PIK3R3 Affinity Capture-Western physical 9415396 IRS1 Two-hybrid physical 8776723 IRS1 Two-hybrid physical 8776723 SHC1 Two-hybrid physical 8776723 GRB10 Two-hybrid physical 8776723 YWHAE Reconstituted Complex physical 9111084 ESR1 Affinity Capture-Western physical 16113100 EGFR Affinity Capture-Western physical 17047074 SHC1 Affinity Capture-Western physical 16113100 CSK Affinity Capture-Western physical 10026153 PTK2 Affinity Capture-Western physical 10082579 IRS1 Affinity Capture-Western physical 10082579 PXN Affinity Capture-Western physical 10082579 PTPN11 Affinity Capture-Western physical 10082579 YWHAB Reconstituted Complex physical 9581554 VAV3 Affinity Capture-Western physical 11094073 GRB10 Reconstituted Complex physical 9506989 SOCS2 Two-hybrid physical 9727029 SOCS2 Reconstituted Complex physical 9727029 SOCS2 Affinity Capture-Western physical 9727029 PTPN11 Affinity Capture-Western physical 7642582 RASA1 Affinity Capture-Western physical 7642582 RASA1 Reconstituted Complex physical 7642582 PTPN11 Reconstituted Complex physical 7642582 GNAI1 Affinity Capture-Western physical 10644671 SOCS3 Reconstituted Complex physical 11071852 SOCS3 Two-hybrid physical 11071852 SOCS3 Affinity Capture-Western physical 11071852 PTPN1 Affinity Capture-Western physical 8999839 GNB2L1 Affinity Capture-Western physical 11884618 GRB10 Two-hybrid physical 8764099 GRB10 Affinity Capture-Western physical 8764099 SHC1 Two-hybrid physical 7559507 UBC Affinity Capture-Western physical 18632619 MDM2 Biochemical Activity physical 18632619 CBL Biochemical Activity physical 18632619 NEDD4 Biochemical Activity physical 18632619 CBL Affinity Capture-Western physical 18632619 MDM2 Affinity Capture-Western physical 18632619 EEA1 Affinity Capture-Western physical 18632619 UBC Affinity Capture-Western physical 17406664 UBC Affinity Capture-Western physical 16619240 UBC Affinity Capture-Western physical 12821780 MDM2 Affinity Capture-Western physical 12821780 MDM2 Affinity Capture-Western physical 12821780 UBC Affinity Capture-Western physical 18070930 EGFR Affinity Capture-Western physical 17307140 EGFR Affinity Capture-Western physical 17307140 ERBB2 Affinity Capture-Western physical 17307140 UBC Affinity Capture-Western physical 17307140 CAMP Reconstituted Complex physical 21685939 CAMP Affinity Capture-Western physical 21685939 SUMO1 Affinity Capture-Western physical 20596523 UBC Affinity Capture-Western physical 19165858 MDM2 Affinity Capture-Western physical 19165858 ARRB2 Affinity Capture-Western physical 19165858 TP53 Affinity Capture-Western physical 19165858 GRB10 Affinity Capture-Western physical 19165858 NEDD4 Affinity Capture-Western physical 19165858 YWHAG Affinity Capture-MS physical 15324660 UBC Affinity Capture-MS physical 21987572