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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for LRP6 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001702gastrulation with mouth forming secondIBA
GO:0001843neural tube closureIBA
GO:0001843neural tube closureIEA
GO:0001933negative regulation of protein phosphorylationIMP
GO:0001947heart loopingIEA
GO:0002053positive regulation of mesenchymal cell proliferationIEA
GO:0003344pericardium morphogenesisIBA
GO:0003344pericardium morphogenesisIEA
GO:0006469negative regulation of protein kinase activityIMP
GO:0006897endocytosisIEA
GO:0007268synaptic transmissionIBA
GO:0007275multicellular organismal developmentIEA
GO:0009880embryonic pattern specificationIBA
GO:0009880embryonic pattern specificationIEA
GO:0009950dorsal/ventral axis specificationIEA
GO:0009952anterior/posterior pattern specificationIBA
GO:0014029neural crest formationIDA
GO:0014033neural crest cell differentiationIDA
GO:0016055Wnt receptor signaling pathwayIDA
GO:0016055Wnt receptor signaling pathwayIMP
GO:0021587cerebellum morphogenesisIBA
GO:0021587cerebellum morphogenesisIEA
GO:0021794thalamus developmentIBA
GO:0021794thalamus developmentIEA
GO:0021795cerebral cortex cell migrationIEA
GO:0021861forebrain radial glial cell differentiationIEA
GO:0021874Wnt receptor signaling pathway involved in forebrain neuroblast divisionIEA
GO:0021915neural tube developmentIEA
GO:0021943formation of radial glial scaffoldsIEA
GO:0021987cerebral cortex developmentIBA
GO:0030278regulation of ossificationIBA
GO:0030326embryonic limb morphogenesisIBA
GO:0030901midbrain developmentIBA
GO:0030901midbrain developmentIEA
GO:0030917midbrain-hindbrain boundary developmentIBA
GO:0030917midbrain-hindbrain boundary developmentIEA
GO:0034392negative regulation of smooth muscle cell apoptosisIMP
GO:0035115embryonic forelimb morphogenesisIEA
GO:0035116embryonic hindlimb morphogenesisIEA
GO:0035121tail morphogenesisIBA
GO:0035121tail morphogenesisIEA
GO:0035261external genitalia morphogenesisIBA
GO:0035261external genitalia morphogenesisIEA
GO:0042074cell migration involved in gastrulationIEA
GO:0042127regulation of cell proliferationIEA
GO:0042475odontogenesis of dentine-containing toothIBA
GO:0042475odontogenesis of dentine-containing toothIEA
GO:0042733embryonic digit morphogenesisIEA
GO:0043065positive regulation of apoptosisIEA
GO:0044332Wnt receptor signaling pathway involved in dorsal/ventral axis specificationIDA
GO:0044335canonical Wnt receptor signaling pathway involved in neural crest cell differentiationIC
GO:0044340canonical Wnt receptor signaling pathway involved in regulation of cell proliferationIC
GO:0045598regulation of fat cell differentiationIBA
GO:0045599negative regulation of fat cell differentiationIEA
GO:0045778positive regulation of ossificationIEA
GO:0045780positive regulation of bone resorptionIEA
GO:0045787positive regulation of cell cycleIMP
GO:0045893positive regulation of transcription, DNA-dependentIEA
GO:0045893positive regulation of transcription, DNA-dependentIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046849bone remodelingIBA
GO:0046849bone remodelingIEA
GO:0048596embryonic camera-type eye morphogenesisIBA
GO:0048596embryonic camera-type eye morphogenesisIEA
GO:0048705skeletal system morphogenesisIEA
GO:0050680negative regulation of epithelial cell proliferationIEA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIEA
GO:0051593response to folic acidIEA
GO:0060021palate developmentIBA
GO:0060021palate developmentIEA
GO:0060026convergent extensionIBA
GO:0060026convergent extensionIEA
GO:0060059embryonic retina morphogenesis in camera-type eyeIBA
GO:0060059embryonic retina morphogenesis in camera-type eyeIEA
GO:0060070canonical Wnt receptor signaling pathwayIDA
GO:0060070canonical Wnt receptor signaling pathwayIEA
GO:0060070canonical Wnt receptor signaling pathwayIMP
GO:0060284regulation of cell developmentIEA
GO:0060325face morphogenesisIBA
GO:0060325face morphogenesisIEA
GO:0060349bone morphogenesisIBA
GO:0060444branching involved in mammary gland duct morphogenesisIBA
GO:0060444branching involved in mammary gland duct morphogenesisIEA
GO:0060535trachea cartilage morphogenesisIBA
GO:0060535trachea cartilage morphogenesisIEA
GO:0060596mammary placode formationIEA
GO:0061310canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart developmentIEA
GO:0061324canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationIEA
GO:0071397cellular response to cholesterolIMP
GO:0071542dopaminergic neuron differentiationIEA
GO:0071901negative regulation of protein serine/threonine kinase activityIDA
GO:0090009primitive streak formationIBA
GO:0090009primitive streak formationIEA
GO:0090118receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportIBA
GO:0090118receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportIEA
GO:0090244Wnt receptor signaling pathway involved in somitogenesisIBA
GO:0090244Wnt receptor signaling pathway involved in somitogenesisIEA
GO:0090245axis elongation involved in somitogenesisIBA
GO:0090245axis elongation involved in somitogenesisIEA
GO:0090263positive regulation of canonical Wnt receptor signaling pathwayIDA
GO:2000055positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specificationIDA
GO:2000149negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesisIEA
GO:2000151negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesisIEA
GO:2000162negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesisIEA
GO:2000164negative regulation of planar cell polarity pathway involved in outflow tract morphogenesisIEA
GO:2000166negative regulation of planar cell polarity pathway involved in pericardium morphogenesisIEA
GO:2000168negative regulation of planar cell polarity pathway involved in neural tube closureIEA
cellular_component
GO:0005624membrane fractionIEA
GO:0005769early endosomeIEA
GO:0005783endoplasmic reticulumIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneIEA
GO:0005901caveolaIDA
GO:0009986cell surfaceIDA
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
GO:0031410cytoplasmic vesicleIDA
GO:0043025neuronal cell bodyIBA
GO:0043235receptor complexIBA
GO:0045202synapseIBA
molecular_function
GO:0004872receptor activityIEA
GO:0005041low-density lipoprotein receptor activityIDA
GO:0005102receptor bindingIPI
GO:0005109frizzled bindingIPI
GO:0005515protein bindingIPI
GO:0017147Wnt-protein bindingIEA
GO:0017147Wnt-protein bindingIPI
GO:0019210kinase inhibitor activityIMP
GO:0019534toxin transporter activityIEA
GO:0019534toxin transporter activityIMP
GO:0034185apolipoprotein bindingIBA
GO:0034185apolipoprotein bindingIEA
GO:0042803protein homodimerization activityIPI
GO:0042813Wnt-activated receptor activityIBA
GO:0071936coreceptor activity involved in Wnt receptor signaling pathwayIDA

Protein-protein interaction details for LRP6 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
MESDC2Affinity Capture-Westernphysical12581525
DKK1Affinity Capture-Westernphysical11448771
DKK1Affinity Capture-Westernphysical11448771
FZD8Affinity Capture-Westernphysical11448771
WNT1Affinity Capture-Westernphysical11448771
UBCAffinity Capture-Westernphysical18378904
NPC1Affinity Capture-Westernphysical18948618
APOBReconstituted Complexphysical18948618
UBCAffinity Capture-Westernphysical20227366