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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for LRP6 (
Homo sapiens
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0001702
gastrulation with mouth forming second
IBA
GO:0001843
neural tube closure
IBA
GO:0001843
neural tube closure
IEA
GO:0001933
negative regulation of protein phosphorylation
IMP
GO:0001947
heart looping
IEA
GO:0002053
positive regulation of mesenchymal cell proliferation
IEA
GO:0003344
pericardium morphogenesis
IBA
GO:0003344
pericardium morphogenesis
IEA
GO:0006469
negative regulation of protein kinase activity
IMP
GO:0006897
endocytosis
IEA
GO:0007268
synaptic transmission
IBA
GO:0007275
multicellular organismal development
IEA
GO:0009880
embryonic pattern specification
IBA
GO:0009880
embryonic pattern specification
IEA
GO:0009950
dorsal/ventral axis specification
IEA
GO:0009952
anterior/posterior pattern specification
IBA
GO:0014029
neural crest formation
IDA
GO:0014033
neural crest cell differentiation
IDA
GO:0016055
Wnt receptor signaling pathway
IDA
GO:0016055
Wnt receptor signaling pathway
IMP
GO:0021587
cerebellum morphogenesis
IBA
GO:0021587
cerebellum morphogenesis
IEA
GO:0021794
thalamus development
IBA
GO:0021794
thalamus development
IEA
GO:0021795
cerebral cortex cell migration
IEA
GO:0021861
forebrain radial glial cell differentiation
IEA
GO:0021874
Wnt receptor signaling pathway involved in forebrain neuroblast division
IEA
GO:0021915
neural tube development
IEA
GO:0021943
formation of radial glial scaffolds
IEA
GO:0021987
cerebral cortex development
IBA
GO:0030278
regulation of ossification
IBA
GO:0030326
embryonic limb morphogenesis
IBA
GO:0030901
midbrain development
IBA
GO:0030901
midbrain development
IEA
GO:0030917
midbrain-hindbrain boundary development
IBA
GO:0030917
midbrain-hindbrain boundary development
IEA
GO:0034392
negative regulation of smooth muscle cell apoptosis
IMP
GO:0035115
embryonic forelimb morphogenesis
IEA
GO:0035116
embryonic hindlimb morphogenesis
IEA
GO:0035121
tail morphogenesis
IBA
GO:0035121
tail morphogenesis
IEA
GO:0035261
external genitalia morphogenesis
IBA
GO:0035261
external genitalia morphogenesis
IEA
GO:0042074
cell migration involved in gastrulation
IEA
GO:0042127
regulation of cell proliferation
IEA
GO:0042475
odontogenesis of dentine-containing tooth
IBA
GO:0042475
odontogenesis of dentine-containing tooth
IEA
GO:0042733
embryonic digit morphogenesis
IEA
GO:0043065
positive regulation of apoptosis
IEA
GO:0044332
Wnt receptor signaling pathway involved in dorsal/ventral axis specification
IDA
GO:0044335
canonical Wnt receptor signaling pathway involved in neural crest cell differentiation
IC
GO:0044340
canonical Wnt receptor signaling pathway involved in regulation of cell proliferation
IC
GO:0045598
regulation of fat cell differentiation
IBA
GO:0045599
negative regulation of fat cell differentiation
IEA
GO:0045778
positive regulation of ossification
IEA
GO:0045780
positive regulation of bone resorption
IEA
GO:0045787
positive regulation of cell cycle
IMP
GO:0045893
positive regulation of transcription, DNA-dependent
IEA
GO:0045893
positive regulation of transcription, DNA-dependent
IMP
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IDA
GO:0046849
bone remodeling
IBA
GO:0046849
bone remodeling
IEA
GO:0048596
embryonic camera-type eye morphogenesis
IBA
GO:0048596
embryonic camera-type eye morphogenesis
IEA
GO:0048705
skeletal system morphogenesis
IEA
GO:0050680
negative regulation of epithelial cell proliferation
IEA
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
IDA
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
IEA
GO:0051593
response to folic acid
IEA
GO:0060021
palate development
IBA
GO:0060021
palate development
IEA
GO:0060026
convergent extension
IBA
GO:0060026
convergent extension
IEA
GO:0060059
embryonic retina morphogenesis in camera-type eye
IBA
GO:0060059
embryonic retina morphogenesis in camera-type eye
IEA
GO:0060070
canonical Wnt receptor signaling pathway
IDA
GO:0060070
canonical Wnt receptor signaling pathway
IEA
GO:0060070
canonical Wnt receptor signaling pathway
IMP
GO:0060284
regulation of cell development
IEA
GO:0060325
face morphogenesis
IBA
GO:0060325
face morphogenesis
IEA
GO:0060349
bone morphogenesis
IBA
GO:0060444
branching involved in mammary gland duct morphogenesis
IBA
GO:0060444
branching involved in mammary gland duct morphogenesis
IEA
GO:0060535
trachea cartilage morphogenesis
IBA
GO:0060535
trachea cartilage morphogenesis
IEA
GO:0060596
mammary placode formation
IEA
GO:0061310
canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart development
IEA
GO:0061324
canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
IEA
GO:0071397
cellular response to cholesterol
IMP
GO:0071542
dopaminergic neuron differentiation
IEA
GO:0071901
negative regulation of protein serine/threonine kinase activity
IDA
GO:0090009
primitive streak formation
IBA
GO:0090009
primitive streak formation
IEA
GO:0090118
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
IBA
GO:0090118
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
IEA
GO:0090244
Wnt receptor signaling pathway involved in somitogenesis
IBA
GO:0090244
Wnt receptor signaling pathway involved in somitogenesis
IEA
GO:0090245
axis elongation involved in somitogenesis
IBA
GO:0090245
axis elongation involved in somitogenesis
IEA
GO:0090263
positive regulation of canonical Wnt receptor signaling pathway
IDA
GO:2000055
positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification
IDA
GO:2000149
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
IEA
GO:2000151
negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
IEA
GO:2000162
negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
IEA
GO:2000164
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
IEA
GO:2000166
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
IEA
GO:2000168
negative regulation of planar cell polarity pathway involved in neural tube closure
IEA
cellular_component
GO:0005624
membrane fraction
IEA
GO:0005769
early endosome
IEA
GO:0005783
endoplasmic reticulum
IEA
GO:0005886
plasma membrane
IDA
GO:0005886
plasma membrane
IEA
GO:0005901
caveola
IDA
GO:0009986
cell surface
IDA
GO:0016020
membrane
IEA
GO:0016021
integral to membrane
IEA
GO:0031410
cytoplasmic vesicle
IDA
GO:0043025
neuronal cell body
IBA
GO:0043235
receptor complex
IBA
GO:0045202
synapse
IBA
molecular_function
GO:0004872
receptor activity
IEA
GO:0005041
low-density lipoprotein receptor activity
IDA
GO:0005102
receptor binding
IPI
GO:0005109
frizzled binding
IPI
GO:0005515
protein binding
IPI
GO:0017147
Wnt-protein binding
IEA
GO:0017147
Wnt-protein binding
IPI
GO:0019210
kinase inhibitor activity
IMP
GO:0019534
toxin transporter activity
IEA
GO:0019534
toxin transporter activity
IMP
GO:0034185
apolipoprotein binding
IBA
GO:0034185
apolipoprotein binding
IEA
GO:0042803
protein homodimerization activity
IPI
GO:0042813
Wnt-activated receptor activity
IBA
GO:0071936
coreceptor activity involved in Wnt receptor signaling pathway
IDA
Protein-protein interaction details for LRP6 (
Homo sapiens
)
(Information is obtained from BioGRID)
Interacting human protein
Experiment
Type
PubMed ID
MESDC2
Affinity Capture-Western
physical
12581525
DKK1
Affinity Capture-Western
physical
11448771
DKK1
Affinity Capture-Western
physical
11448771
FZD8
Affinity Capture-Western
physical
11448771
WNT1
Affinity Capture-Western
physical
11448771
UBC
Affinity Capture-Western
physical
18378904
NPC1
Affinity Capture-Western
physical
18948618
APOB
Reconstituted Complex
physical
18948618
UBC
Affinity Capture-Western
physical
20227366