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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for MEN1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0000165 MAPKKK cascade IDA GO:0001503 ossification IEA GO:0001776 leukocyte homeostasis IEA GO:0001933 negative regulation of protein phosphorylation IDA GO:0002076 osteoblast development IEA GO:0002076 osteoblast development IGI GO:0006281 DNA repair NAS GO:0006338 chromatin remodeling IEA GO:0006974 response to DNA damage stimulus IDA GO:0007050 cell cycle arrest IEA GO:0007420 brain development IEA GO:0008285 negative regulation of cell proliferation IDA GO:0008285 negative regulation of cell proliferation IEA GO:0009411 response to UV IDA GO:0009790 embryo development IEA GO:0010332 response to gamma radiation IDA GO:0030097 hemopoiesis IEA GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP GO:0031062 positive regulation of histone methylation IEA GO:0032092 positive regulation of protein binding IDA GO:0032925 regulation of activin receptor signaling pathway IEA GO:0034968 histone lysine methylation IDA GO:0043065 positive regulation of apoptosis IEA GO:0043280 positive regulation of caspase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA GO:0045668 negative regulation of osteoblast differentiation IEA GO:0045668 negative regulation of osteoblast differentiation IGI GO:0045669 positive regulation of osteoblast differentiation IEA GO:0045736 negative regulation of cyclin-dependent protein kinase activity IMP GO:0045786 negative regulation of cell cycle IDA GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046329 negative regulation of JNK cascade IDA GO:0046621 negative regulation of organ growth IEA GO:0048704 embryonic skeletal system morphogenesis IEA GO:0051781 positive regulation of cell division IEA GO:0051974 negative regulation of telomerase activity IMP GO:0060021 palate development IEA GO:0060135 maternal process involved in female pregnancy IEA cellular_component GO:0000785 chromatin IDA GO:0005625 soluble fraction IDA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005829 cytosol IDA GO:0016363 nuclear matrix IDA GO:0032154 cleavage furrow IDA GO:0035097 histone methyltransferase complex IDA GO:0035097 histone methyltransferase complex IPI GO:0043234 protein complex IDA molecular_function GO:0000400 four-way junction DNA binding IDA GO:0000403 Y-form DNA binding IDA GO:0003677 DNA binding IEA GO:0003682 chromatin binding IEA GO:0003690 double-stranded DNA binding IDA GO:0005515 protein binding IPI GO:0018024 histone-lysine N-methyltransferase activity IDA GO:0030674 protein binding, bridging IDA GO:0044212 transcription regulatory region DNA binding IDA GO:0047485 protein N-terminus binding IPI GO:0070412 R-SMAD binding IPI

Protein-protein interaction details for MEN1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RPRM Affinity Capture-MS physical 17353931 ASH2L Reconstituted Complex physical 15199122 HCFC1 Co-purification physical 15199122 HCFC2 Co-purification physical 15199122 MLL Co-purification physical 15199122 MLL Affinity Capture-Western physical 15199122 MLL Affinity Capture-Western physical 15199122 RBBP5 Co-purification physical 15199122 WDR5 Co-purification physical 15199122 FANCD2 Affinity Capture-Western physical 12874027 FANCD2 Reconstituted Complex physical 12874027 NFKB1 Affinity Capture-Western physical 11526476 NFKB1 Reconstituted Complex physical 11526476 RELA Reconstituted Complex physical 11526476 NFKB2 Reconstituted Complex physical 11526476 RELA Affinity Capture-Western physical 11526476 JUND Two-hybrid physical 9989505 JUND Affinity Capture-Western physical 9989505 JUND Reconstituted Complex physical 9989505 SMAD3 Affinity Capture-Western physical 11274402 RPA2 Two-hybrid physical 12509449 RPA2 Reconstituted Complex physical 12509449 RPA2 Affinity Capture-Western physical 12509449 GFAP Affinity Capture-Western physical 12169273 VIM Affinity Capture-Western physical 12169273 GFAP Reconstituted Complex physical 12169273 VIM Reconstituted Complex physical 12169273 CXXC1 Affinity Capture-Western physical 18082152 MYB Affinity Capture-Western physical 20093773 MLL Co-localization physical 20064463 CTNNB1 Reconstituted Complex physical 16510874 CTNNB1 Affinity Capture-Western physical 19074834 TCF4 Reconstituted Complex physical 19074834 TCF3 Reconstituted Complex physical 19074834 CTNNB1 Reconstituted Complex physical 19074834 TCF4 Affinity Capture-Western physical 19074834 TCF3 Affinity Capture-Western physical 19074834 SNW1 Affinity Capture-Western physical 19818711 MYC Affinity Capture-Western physical 19818711 SNW1 Affinity Capture-Western physical 19818711 MLL Affinity Capture-Western physical 19818711 MYC Affinity Capture-Western physical 19818711 SNW1 Reconstituted Complex physical 19818711 MYC Reconstituted Complex physical 19818711 HIST1H3A Biochemical Activity physical 17050672 ASH2L Affinity Capture-Western physical 17050672 RBBP5 Affinity Capture-Western physical 17050672 POLR2A Affinity Capture-Western physical 17050672 FOXN3 Affinity Capture-Western physical 16951149 FOXN3 Affinity Capture-Western physical 16951149 FOXN3 Reconstituted Complex physical 16951149 FOXN3 Reconstituted Complex physical 16951149 ESR1 Two-hybrid physical 16651450 JUND Affinity Capture-Western physical 16651450 NFKB1 Affinity Capture-Western physical 16651450 ESR1 Affinity Capture-Western physical 16651450 MLL Affinity Capture-Western physical 16618927 UBC Affinity Capture-Western physical 15254225 HSPA4 Affinity Capture-Western physical 15254225 STUB1 Affinity Capture-Western physical 15254225 CTNNB1 Reconstituted Complex physical 16510875 PSIP1 Affinity Capture-Western physical 18598942 SIN3A Reconstituted Complex physical 14559791 HDAC1 Reconstituted Complex physical 14559791 HDAC2 Reconstituted Complex physical 14559791 SIN3A Affinity Capture-Western physical 14559791 MLL Affinity Capture-Western physical 16239140 MLLT4 Affinity Capture-Western physical 16239140 MLL Reconstituted Complex physical 16239140 POLR2A Reconstituted Complex physical 16199523 MLL Affinity Capture-Western physical 16199523 POLR2A Co-localization physical 16199523 MLL Co-localization physical 16199523 TP53 Reconstituted Complex physical 15960975 HSPA4 Affinity Capture-MS physical 15254225 HSPA8 Affinity Capture-MS physical 15254225 JUND Two-hybrid physical 10500243 JUND Reconstituted Complex physical 10500243 MEF2D Affinity Capture-Western physical 18026121 MLL Affinity Capture-Western physical 17671196 WT1 Affinity Capture-Western physical 21378168 WT1 Affinity Capture-Western physical 21378168 CHEK1 Affinity Capture-Western physical 20969866 CHEK1 Affinity Capture-Western physical 20969866 SMAD1 Affinity Capture-Western physical 12649288 SMAD5 Affinity Capture-Western physical 12649288