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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for PARK2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000209 protein polyubiquitination IDA GO:0000422 mitochondrion degradation IMP GO:0001933 negative regulation of protein phosphorylation IDA GO:0001964 startle response IEA GO:0006511 ubiquitin-dependent protein catabolic process IDA GO:0006513 protein monoubiquitination IDA GO:0007417 central nervous system development TAS GO:0007612 learning IEA GO:0008219 cell death IDA GO:0008344 adult locomotory behavior IEA GO:0010506 regulation of autophagy IDA GO:0019538 protein metabolic process IEA GO:0032232 negative regulation of actin filament bundle assembly IDA GO:0035249 synaptic transmission, glutamatergic IEA GO:0042415 norepinephrine metabolic process IEA GO:0042417 dopamine metabolic process IEA GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IDA GO:0046928 regulation of neurotransmitter secretion IEA GO:0051583 dopamine uptake IEA GO:0051865 protein autoubiquitination IDA GO:0060548 negative regulation of cell death IDA GO:0070534 protein K63-linked ubiquitination IDA GO:0070842 aggresome assembly IMP GO:0070936 protein K48-linked ubiquitination IDA GO:0070997 neuron death IDA GO:0090201 negative regulation of release of cytochrome c from mitochondria IDA GO:2000377 regulation of reactive oxygen species metabolic process IMP cellular_component GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005739 mitochondrion IDA GO:0005739 mitochondrion IMP GO:0005783 endoplasmic reticulum IEA GO:0005794 Golgi apparatus IDA GO:0005829 cytosol IDA GO:0016235 aggresome IDA GO:0043005 neuron projection IEA GO:0043234 protein complex IEA GO:0048471 perinuclear region of cytoplasm IDA molecular_function GO:0004842 ubiquitin-protein ligase activity IDA GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0016874 ligase activity IEA GO:0016881 acid-amino acid ligase activity IEA GO:0019900 kinase binding IPI GO:0019901 protein kinase binding IPI GO:0030165 PDZ domain binding IPI GO:0031625 ubiquitin protein ligase binding IPI GO:0046872 metal ion binding IEA GO:0051087 chaperone binding IPI

Protein-protein interaction details for PARK2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID TRIP13 Two-hybrid physical 16189514 SEPT5 Two-hybrid physical 14559152 SEPT5 Affinity Capture-Western physical 14559152 SEPT5 Biochemical Activity physical 14559152 SYT11 Two-hybrid physical 12925569 SYT11 Affinity Capture-Western physical 12925569 SYT11 Reconstituted Complex physical 12925569 AIMP2 Affinity Capture-Western physical 12783850 AIMP2 Two-hybrid physical 12783850 FBXW7 Affinity Capture-Western physical 12628165 FBXW7 Affinity Capture-Western physical 12628165 FBXW7 Reconstituted Complex physical 12628165 CUL1 Affinity Capture-Western physical 12628165 CUL1 Reconstituted Complex physical 12628165 CCNE1 Affinity Capture-Western physical 12628165 CCNA1 Affinity Capture-Western physical 12628165 NDUFA4L2 Two-hybrid physical 16169070 RAC1 Two-hybrid physical 16169070 RAD1 Two-hybrid physical 16169070 PAFAH1B2 Two-hybrid physical 16169070 RGS2 Two-hybrid physical 16169070 CASK Reconstituted Complex physical 11679592 CASK Co-fractionation physical 11679592 CASK Affinity Capture-Western physical 11679592 GRIN2B Affinity Capture-Western physical 11679592 DLG4 Affinity Capture-Western physical 11679592 HOMER1 Affinity Capture-Western physical 11679592 CAMK2A Affinity Capture-Western physical 11679592 GPR37 Two-hybrid physical 11439185 GPR37 Affinity Capture-Western physical 11439185 UBE2G1 Affinity Capture-Western physical 11439185 UBE2J1 Affinity Capture-Western physical 11439185 SNCA Affinity Capture-Western physical 11588587 SNCA Affinity Capture-Western physical 11588587 HSPA1A Affinity Capture-MS physical 12150907 STUB1 Affinity Capture-MS physical 12150907 STUB1 Affinity Capture-Western physical 12150907 DNAJA1 Affinity Capture-Western physical 12150907 HSPA8 Affinity Capture-Western physical 12150907 DNAJB1 Affinity Capture-Western physical 12150907 HSPA1A Affinity Capture-Western physical 12150907 STUB1 Reconstituted Complex physical 12150907 GPR37 Reconstituted Complex physical 12150907 HSPA1A Reconstituted Complex physical 12150907 HSPA8 Reconstituted Complex physical 12150907 PSMA1 Reconstituted Complex physical 12150907 GPR37 Biochemical Activity physical 12150907 SNCAIP Affinity Capture-Western physical 11590439 SNCAIP Affinity Capture-Western physical 11590439 SNCAIP Biochemical Activity physical 11590439 UBE2L6 Affinity Capture-Western physical 11078524 PDCD2 Affinity Capture-Western physical 19146857 PDCD2 Affinity Capture-Western physical 19146857 PDCD2 Biochemical Activity physical 19146857 SEPT5 Affinity Capture-Western physical 18845538 RNF41 Biochemical Activity physical 18541373 UBC Affinity Capture-Western physical 18541373 PLCG1 Affinity Capture-Western physical 18671761 MAPT Affinity Capture-Western physical 18248624 HSPA4 Affinity Capture-Western physical 18248624 UBC Affinity Capture-Western physical 18195004 SNCA Affinity Capture-Western physical 18195004 PARK2 Affinity Capture-Western physical 17883392 BACH1 Affinity Capture-Western physical 17682061 CDK5 Affinity Capture-Western physical 17327227 UBC Affinity Capture-Western physical 17327227 CDK5 Biochemical Activity physical 17327227 LIMK1 Affinity Capture-Western physical 17512523 LIMK1 Affinity Capture-Western physical 17512523 UBC Affinity Capture-Western physical 17512523 EPS15 Reconstituted Complex physical 16862145 EPS15 Biochemical Activity physical 16862145 UBC Affinity Capture-Western physical 16714300 HSPA4 Affinity Capture-Western physical 16714300 TUBA1A Affinity Capture-Western physical 16714300 TUBG1 Affinity Capture-Western physical 16714300 SEPT5 Affinity Capture-Western physical 16714300 AIMP2 Affinity Capture-Western physical 16714300 PSMA4 Affinity Capture-Western physical 16714300 SNCA Affinity Capture-Western physical 16714300 PARK2 Biochemical Activity physical 16714300 EP300 Affinity Capture-Western physical 19297328 LRRK2 Affinity Capture-Western physical 16352719 LRRK2 Affinity Capture-Western physical 16352719 UBC Affinity Capture-Western physical 16352719 RANBP2 Affinity Capture-Western physical 16332688 RANBP2 Reconstituted Complex physical 16332688 RANBP2 Biochemical Activity physical 16332688 HDAC4 Affinity Capture-Western physical 16332688 AIMP2 Reconstituted Complex physical 16135753 AIMP2 Affinity Capture-Western physical 16135753 AIMP2 Affinity Capture-Western physical 16135753 UBC Affinity Capture-Western physical 16049031 SNCAIP Affinity Capture-Western physical 16049031 AIMP2 Affinity Capture-Western physical 16049031 PSMA4 Two-hybrid physical 15987638 PSMA4 Affinity Capture-Western physical 15987638 PSMA4 Affinity Capture-Western physical 15987638 SIM2 Affinity Capture-Western physical 15963499 SIM2 Affinity Capture-Western physical 15963499 SNCAIP Affinity Capture-Western physical 15944382 PARK7 Affinity Capture-Western physical 15525661 PARK7 Affinity Capture-Western physical 15525661 SLC6A3 Affinity Capture-Western physical 15492001 MAPT Affinity Capture-Western physical 14962978 TUBG1 Affinity Capture-Western physical 12928331 HSPA4 Affinity Capture-Western physical 12676955 PSMC5 Affinity Capture-Western physical 12676955 PSMC5 Reconstituted Complex physical 12676955 PARK7 Biochemical Activity physical 17846173 PARK7 Affinity Capture-Western physical 17846173 PARK7 Reconstituted Complex physical 17846173 UBE2L3 Affinity Capture-Western physical 11431533 SYN1 Affinity Capture-Western physical 11431533 UBC Affinity Capture-Western physical 10973942 UBE2L3 Affinity Capture-Western physical 10973942 HTRA2 Affinity Capture-Western physical 19631192 BCL2 Reconstituted Complex physical 20889974 BCL2 Affinity Capture-Western physical 20889974 RNF41 Reconstituted Complex physical 15632191 RNF41 Reconstituted Complex physical 15632191 RNF41 Affinity Capture-Western physical 15632191 RNF41 Affinity Capture-Western physical 15632191 FBP1 Affinity Capture-Western physical 16672220 UBC Affinity Capture-Western physical 15456787 APP Affinity Capture-Western physical 19610108 PINK1 Reconstituted Complex physical 19358826 PINK1 Affinity Capture-Western physical 19358826 ZNF746 Affinity Capture-Western physical 21376232 ZNF746 Reconstituted Complex physical 21376232 ZNF746 Affinity Capture-Western physical 21376232 ZNF746 Biochemical Activity physical 21376232 ABL1 Reconstituted Complex physical 20823226 ABL1 Affinity Capture-Western physical 20823226 ABL1 Affinity Capture-Western physical 20823226 UBC Affinity Capture-Western physical 20823226 AMBRA1 Affinity Capture-Western physical 21753002 AMBRA1 Affinity Capture-Western physical 21753002 AMBRA1 Affinity Capture-MS physical 21753002 PICK1 Reconstituted Complex physical 17553932 PICK1 Affinity Capture-Western physical 17553932 PICK1 Affinity Capture-Western physical 17553932 PARK2 Biochemical Activity physical 17553932 IKBKG Affinity Capture-Western physical 17314283 TRAF2 Affinity Capture-Western physical 17314283 IKBKG Affinity Capture-Western physical 17314283 TRAF2 Affinity Capture-Western physical 17314283 SLC11A2 Affinity Capture-Western physical 20089134 SLC11A2 Co-localization physical 20089134 MFN1 Affinity Capture-Western physical 21615408 MFN2 Affinity Capture-Western physical 21615408 MFN1 Biochemical Activity physical 21615408 ABL1 Biochemical Activity physical 20823226 PICK1 Biochemical Activity physical 17553932 ESRRA Affinity Capture-Western physical 21177257 ESRRA Affinity Capture-Western physical 21177257 ESRRB Affinity Capture-Western physical 21177257 ESRRG Affinity Capture-Western physical 21177257 SNCAIP Affinity Capture-Western physical 20089136 UBE2L3 Affinity Capture-Western physical 20089136 UBE2E2 Affinity Capture-Western physical 20089136 ARRB2 Affinity Capture-Western physical 21466165 ARRB2 Affinity Capture-Western physical 21466165 ARRB1 Affinity Capture-Western physical 21466165 ARR3 Affinity Capture-Western physical 21466165 ARRB2 Reconstituted Complex physical 21466165 ARR3 Reconstituted Complex physical 21466165 ATXN3 Reconstituted Complex physical 20940148 ATXN3 Affinity Capture-Western physical 20940148 PARK2 Biochemical Activity physical 20940148 UBC Affinity Capture-Western physical 20940148 ATXN3 Biochemical Activity physical 20940148 PSMD4 Reconstituted Complex physical 19875440 DNM1L Affinity Capture-Western physical 21292769 DNM1L Affinity Capture-Western physical 21292769 DNM1L Reconstituted Complex physical 21292769 DNM1L Biochemical Activity physical 21292769 C1QBP Affinity Capture-Western physical 22008525 UBC Affinity Capture-Western physical 22008525 PARK2 Biochemical Activity physical 22008525 HSPA4 Affinity Capture-Western physical 18784277 PSMD4 Biochemical Activity physical 19240029 RGS2 Two-hybrid physical 21900206 ATXN3 Biochemical Activity physical 22081612 ATXN3 Reconstituted Complex physical 22081612 ATXN3 Affinity Capture-Western physical 22081612 PARK2 Affinity Capture-Western physical 22200450 PARK2 Reconstituted Complex physical 22200450 UBC Co-localization physical 20890124 SQSTM1 Co-localization physical 20890124 ABL1 Reconstituted Complex physical 21209200 ABL1 Reconstituted Complex physical 21209200 ABL1 Biochemical Activity physical 21209200 PARK2 Biochemical Activity physical 21209200 UBC Reconstituted Complex physical 21209200 FBP1 Biochemical Activity physical 21209200 UBC Affinity Capture-Western physical 21209200 ABL1 Affinity Capture-Western physical 21209200 ABL1 Affinity Capture-Western physical 21209200 GBA Affinity Capture-Western physical 20643691 GBA Affinity Capture-Western physical 20643691