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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for SREBF1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0003062 regulation of heart rate by chemical signal IEA GO:0006351 transcription, DNA-dependent IDA GO:0006355 regulation of transcription, DNA-dependent IDA GO:0006355 regulation of transcription, DNA-dependent IEA GO:0006357 regulation of transcription from RNA polymerase II promoter TAS GO:0006629 lipid metabolic process TAS GO:0007568 aging IEA GO:0008202 steroid metabolic process IEA GO:0008203 cholesterol metabolic process IEA GO:0008286 insulin receptor signaling pathway IEA GO:0008610 lipid biosynthetic process ISS GO:0009267 cellular response to starvation IEA GO:0009267 cellular response to starvation ISS GO:0009749 response to glucose stimulus IEA GO:0010867 positive regulation of triglyceride biosynthetic process IEA GO:0010867 positive regulation of triglyceride biosynthetic process ISS GO:0019217 regulation of fatty acid metabolic process IEA GO:0030324 lung development IEA GO:0031065 positive regulation of histone deacetylation IEA GO:0032094 response to food IEA GO:0032526 response to retinoic acid IEA GO:0032570 response to progesterone stimulus IEA GO:0033762 response to glucagon stimulus IEA GO:0035104 positive regulation of transcription via sterol regulatory element binding IEA GO:0042493 response to drug IEA GO:0045542 positive regulation of cholesterol biosynthetic process IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA GO:0046676 negative regulation of insulin secretion IEA GO:0051591 response to cAMP IEA GO:0070542 response to fatty acid IEA cellular_component GO:0000139 Golgi membrane IEA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005635 nuclear envelope TAS GO:0005737 cytoplasm IEA GO:0005783 endoplasmic reticulum IDA GO:0005783 endoplasmic reticulum IEA GO:0005789 endoplasmic reticulum membrane IEA GO:0005792 microsome IEA GO:0005794 Golgi apparatus IEA GO:0012507 ER to Golgi transport vesicle membrane IEA GO:0016020 membrane IEA GO:0016021 integral to membrane IEA GO:0031410 cytoplasmic vesicle IEA GO:0043234 protein complex IEA GO:0044444 cytoplasmic part ISS molecular_function GO:0003677 DNA binding ISS GO:0003682 chromatin binding IEA GO:0003700 sequence-specific DNA binding transcription factor activity IDA GO:0005515 protein binding IPI GO:0032810 sterol response element binding IDA GO:0043565 sequence-specific DNA binding IEA

Protein-protein interaction details for SREBF1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID LMNA Two-hybrid physical 11929849 TWIST2 Two-hybrid physical 14654692 TWIST2 Reconstituted Complex physical 14654692 UBE2I Affinity Capture-Western physical 12615929 CREBBP Far Western physical 8918891 CREBBP Affinity Capture-Western physical 8918891 YY1 Reconstituted Complex physical 10224053 SP1 Reconstituted Complex physical 10224053 NR0B1 Reconstituted Complex physical 11713202 NR0B1 Two-hybrid physical 11713202 MAPK3 Biochemical Activity physical 10627507 MAPK1 Biochemical Activity physical 10627507 LMNA Reconstituted Complex physical 11929849 LMNA Affinity Capture-Western physical 11929849 FBXW7 Affinity Capture-Western physical 16054087 FBXW7 Protein-peptide physical 16054087 KLF13 Reconstituted Complex physical 16303770 EP300 Affinity Capture-Western physical 14615581 UBC Affinity Capture-Western physical 14615581 EP300 Affinity Capture-Western physical 12640139 EP300 Reconstituted Complex physical 12640139 UBC Affinity Capture-Western physical 12640139 AR Affinity Capture-Western physical 18245227 AR Reconstituted Complex physical 18245227 SP1 Co-purification physical 10235267 EP300 Co-purification physical 10235267 CREBBP Co-purification physical 10235267 EP300 Reconstituted Complex physical 10235267 CREBBP Reconstituted Complex physical 10235267 MED15 Reconstituted Complex physical 10235267 MED23 Reconstituted Complex physical 10235267 MED7 Reconstituted Complex physical 10235267 MED13 Co-purification physical 10235267 MED12 Co-purification physical 10235267 MED1 Co-purification physical 10235267 MED14 Co-purification physical 10235267 MED23 Co-purification physical 10235267 MED24 Co-purification physical 10235267 MED26 Co-purification physical 10235267 MED7 Co-purification physical 10235267 MED6 Co-purification physical 10235267 CREBBP Reconstituted Complex physical 9765204 HNF4A Reconstituted Complex physical 17636037 MED15 Affinity Capture-Western physical 20534441 TRRAP Affinity Capture-Western physical 20534441 KAT2A Affinity Capture-Western physical 20534441 ATM Affinity Capture-Western physical 20534441 EP300 Affinity Capture-Western physical 20534441 GCN1L1 Affinity Capture-Western physical 20534441 TADA2B Affinity Capture-Western physical 20534441 TADA3 Affinity Capture-Western physical 20534441 RUVBL2 Affinity Capture-Western physical 20534441 SIRT1 Biochemical Activity physical 20595232 UBC Affinity Capture-Western physical 20595232 MED12 Affinity Capture-MS physical 11834832 MED13 Affinity Capture-MS physical 11834832 MED23 Affinity Capture-MS physical 11834832 MED14 Affinity Capture-MS physical 11834832 MED15 Affinity Capture-MS physical 11834832 MED24 Affinity Capture-MS physical 11834832 MED25 Affinity Capture-MS physical 11834832 MED17 Affinity Capture-MS physical 11834832 MED26 Affinity Capture-MS physical 11834832 MED7 Affinity Capture-MS physical 11834832 MED6 Affinity Capture-MS physical 11834832 MED21 Affinity Capture-MS physical 11834832 CDK8 Affinity Capture-MS physical 11834832 USF1 Affinity Capture-Western physical 19303849 GSK3B Biochemical Activity physical 19126544 FBXW7 Affinity Capture-Western physical 19126544 CREBBP Co-localization physical 16799563 MED15 Co-crystal Structure physical 16799563 MED1 Co-localization physical 16799563 MED15 Reconstituted Complex physical 16799563 CREBBP Reconstituted Complex physical 16799563 CDK8 Reconstituted Complex physical 16799563 MED6 Reconstituted Complex physical 16799563 MED1 Reconstituted Complex physical 16799563 MED13 Reconstituted Complex physical 16799563 MED12 Reconstituted Complex physical 16799563 MED14 Reconstituted Complex physical 16799563 MED23 Reconstituted Complex physical 16799563 MED24 Reconstituted Complex physical 16799563 MED25 Reconstituted Complex physical 16799563 MED17 Reconstituted Complex physical 16799563 MED26 Reconstituted Complex physical 16799563 MED15 Reconstituted Complex physical 16799563 CREBBP Reconstituted Complex physical 16799563 MED15 Co-localization physical 16799563 UBC Affinity Capture-MS physical 21987572