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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ADAM10 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001701in utero embryonic developmentIEA
GO:0001701in utero embryonic developmentISS
GO:0006468protein phosphorylationIEA
GO:0006468protein phosphorylationISS
GO:0006508proteolysisIEA
GO:0006509membrane protein ectodomain proteolysisIDA
GO:0006509membrane protein ectodomain proteolysisIMP
GO:0007162negative regulation of cell adhesionIDA
GO:0007162negative regulation of cell adhesionNAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007219Notch signaling pathwayIEA
GO:0007219Notch signaling pathwayISS
GO:0007219Notch signaling pathwayTAS
GO:0007220Notch receptor processingTAS
GO:0007229integrin-mediated signaling pathwayIEA
GO:0007229integrin-mediated signaling pathwayNAS
GO:0007267cell-cell signalingNAS
GO:0008284positive regulation of cell proliferationIMP
GO:0010820positive regulation of T cell chemotaxisIMP
GO:0030307positive regulation of cell growthIMP
GO:0030335positive regulation of cell migrationIMP
GO:0034612response to tumor necrosis factorIDA
GO:0042117monocyte activationIMP
GO:0051088PMA-inducible membrane protein ectodomain proteolysisIMP
GO:0051089constitutive protein ectodomain proteolysisIDA
cellular_component
GO:0005634nucleusIEA
GO:0005634nucleusISS
GO:0005737cytoplasmIEA
GO:0005737cytoplasmISS
GO:0005794Golgi apparatusIDA
GO:0005798Golgi-associated vesicleIDA
GO:0005886plasma membraneIEA
GO:0005886plasma membraneTAS
GO:0009986cell surfaceIDA
GO:0012505endomembrane systemIEA
GO:0014069postsynaptic densityIEA
GO:0016021integral to membraneNAS
molecular_function
GO:0004175endopeptidase activityISS
GO:0004222metalloendopeptidase activityIEA
GO:0004222metalloendopeptidase activityNAS
GO:0005102receptor bindingNAS
GO:0005178integrin bindingNAS
GO:0005515protein bindingIPI
GO:0008233peptidase activityIEA
GO:0008237metallopeptidase activityIDA
GO:0008237metallopeptidase activityIMP
GO:0008237metallopeptidase activityTAS
GO:0008270zinc ion bindingIEA
GO:0017124SH3 domain bindingIEA
GO:0019901protein kinase bindingIEA
GO:0019901protein kinase bindingISS
GO:0042803protein homodimerization activityIEA
GO:0042803protein homodimerization activityISS
GO:0046872metal ion bindingIEA

Protein-protein interaction details for ADAM10 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
EFNA2Affinity Capture-Westernphysical10958785
MAD2L1Affinity Capture-Westernphysical11741929
GRB2Affinity Capture-Westernphysical11741929
LCKAffinity Capture-Westernphysical11741929
UBCAffinity Capture-MSphysical18781797