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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ADORA2A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001963 synaptic transmission, dopaminergic IEA GO:0001975 response to amphetamine IEA GO:0006171 cAMP biosynthetic process TAS GO:0006355 regulation of transcription, DNA-dependent IEA GO:0006469 negative regulation of protein kinase activity IEA GO:0006909 phagocytosis TAS GO:0006915 apoptosis TAS GO:0006954 inflammatory response TAS GO:0006968 cellular defense response TAS GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger TAS GO:0007189 activation of adenylate cyclase activity by G-protein signaling pathway IEA GO:0007190 activation of adenylate cyclase activity TAS GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway IEA GO:0007267 cell-cell signaling TAS GO:0007271 synaptic transmission, cholinergic IEA GO:0007417 central nervous system development TAS GO:0007596 blood coagulation TAS GO:0007600 sensory perception TAS GO:0007626 locomotory behavior IEA GO:0008015 blood circulation TAS GO:0008285 negative regulation of cell proliferation IEA GO:0014049 positive regulation of glutamate secretion IEA GO:0014057 positive regulation of acetylcholine secretion IEA GO:0014061 regulation of norepinephrine secretion IEA GO:0030819 positive regulation of cAMP biosynthetic process IEA GO:0031000 response to caffeine IEA GO:0031558 induction of apoptosis in response to chemical stimulus IEA GO:0032230 positive regulation of synaptic transmission, GABAergic IEA GO:0035810 positive regulation of urine volume IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0040013 negative regulation of locomotion IEA GO:0042311 vasodilation IEA GO:0042493 response to drug IEA GO:0042755 eating behavior IEA GO:0043116 negative regulation of vascular permeability IEA GO:0043154 negative regulation of caspase activity IEA GO:0043524 negative regulation of neuron apoptosis IEA GO:0046636 negative regulation of alpha-beta T cell activation IEA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048143 astrocyte activation IEA GO:0048167 regulation of synaptic plasticity IEA GO:0048812 neuron projection morphogenesis IEA GO:0050714 positive regulation of protein secretion IEA GO:0050728 negative regulation of inflammatory response IEA GO:0051881 regulation of mitochondrial membrane potential IEA GO:0051925 regulation of calcium ion transport via voltage-gated calcium channel activity IEA GO:0051968 positive regulation of synaptic transmission, glutamatergic IEA GO:0060079 regulation of excitatory postsynaptic membrane potential IEA GO:0060080 regulation of inhibitory postsynaptic membrane potential IEA GO:0060134 prepulse inhibition IEA cellular_component GO:0000139 Golgi membrane IEA GO:0005624 membrane fraction IEA GO:0005624 membrane fraction TAS GO:0005882 intermediate filament IEA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane TAS GO:0014069 postsynaptic density IEA GO:0016021 integral to membrane IEA GO:0030424 axon IEA GO:0030425 dendrite IEA GO:0030673 axolemma IEA GO:0032279 asymmetric synapse IEA GO:0042734 presynaptic membrane IEA GO:0043025 neuronal cell body IEA GO:0044446 intracellular organelle part IDA GO:0045211 postsynaptic membrane IEA GO:0048786 presynaptic active zone IEA molecular_function GO:0001609 adenosine receptor activity, G-protein coupled IEA GO:0004871 signal transducer activity IEA GO:0004872 receptor activity IEA GO:0005515 protein binding IPI GO:0019899 enzyme binding IPI GO:0031802 type 5 metabotropic glutamate receptor binding IEA GO:0046982 protein heterodimerization activity IEA GO:0051372 nonmuscle alpha-actinin binding IEA

Protein-protein interaction details for ADORA2A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID DRD2 Affinity Capture-Western physical 12804599 ADORA2A FRET physical 12804599 DRD2 FRET physical 12804599 ADA Affinity Capture-Western physical 11125033