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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ABCA1 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0002790peptide secretionIEA
GO:0006497protein lipidationIEA
GO:0006629lipid metabolic processTAS
GO:0006810transportIEA
GO:0006820anion transportISS
GO:0006911phagocytosis, engulfmentIEA
GO:0007040lysosome organizationIDA
GO:0007186G-protein coupled receptor protein signaling pathwayIMP
GO:0008202steroid metabolic processIEA
GO:0008203cholesterol metabolic processIDA
GO:0010745negative regulation of macrophage derived foam cell differentiationTAS
GO:0010875positive regulation of cholesterol effluxIEA
GO:0010887negative regulation of cholesterol storageTAS
GO:0016197endosome transportIDA
GO:0030819positive regulation of cAMP biosynthetic processIMP
GO:0032367intracellular cholesterol transportIMP
GO:0032488Cdc42 protein signal transductionIMP
GO:0033344cholesterol effluxIDA
GO:0033344cholesterol effluxIMP
GO:0033700phospholipid effluxIDA
GO:0033700phospholipid effluxIMP
GO:0034380high-density lipoprotein particle assemblyIMP
GO:0038027apolipoprotein A-I-mediated signaling pathwayIDA
GO:0042157lipoprotein metabolic processTAS
GO:0042632cholesterol homeostasisIDA
GO:0043691reverse cholesterol transportIMP
GO:0044255cellular lipid metabolic processTAS
GO:0045332phospholipid translocationIEA
GO:0050702interleukin-1 beta secretionIMP
GO:0055091phospholipid homeostasisIMP
GO:0060155platelet dense granule organizationIMP
GO:0071222cellular response to lipopolysaccharideIEA
GO:0071300cellular response to retinoic acidIEA
cellular_component
GO:0005622intracellularIMP
GO:0005624membrane fractionIDA
GO:0005794Golgi apparatusIEA
GO:0005886plasma membraneTAS
GO:0005887integral to plasma membraneIDA
GO:0030139endocytic vesicleIDA
GO:0045121membrane raftIDA
GO:0045335phagocytic vesicleIDA
molecular_function
GO:0000166nucleotide bindingIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0005524ATP bindingIEA
GO:0005543phospholipid bindingIC
GO:0005548phospholipid transporter activityIDA
GO:0008509anion transmembrane transporter activityISS
GO:0015485cholesterol bindingIC
GO:0016887ATPase activityIEA
GO:0017127cholesterol transporter activityIDA
GO:0030349syntaxin-13 bindingIPI
GO:0031267small GTPase bindingIPI
GO:0034185apolipoprotein bindingIPI
GO:0034186apolipoprotein A-I bindingIPI
GO:0034188apolipoprotein A-I receptor activityIDA

Protein-protein interaction details for ABCA1 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
FADDTwo-hybridphysical12235128
CREBBPAffinity Capture-Westernphysical11864601
FADDReconstituted Complexphysical12235128
FADDReconstituted Complexphysical12235128
APOA1Reconstituted Complexphysical12084722
APOA1Reconstituted Complexphysical12084722
XPCReconstituted Complexphysical12505994
XPCTwo-hybridphysical12505994
XPCTwo-hybridphysical12505994
SNTB2Two-hybridphysical12054535
UGP1Two-hybridphysical12054535
SDHBTwo-hybridphysical12054535
AOX1Two-hybridphysical12054535
PRPF8Two-hybridphysical12054535
SNTB2Affinity Capture-Westernphysical12054535
UBCAffinity Capture-Westernphysical21520210
HGSAffinity Capture-Westernphysical21520210
COPS5Affinity Capture-Westernphysical19268428
COPS5Affinity Capture-Westernphysical19268428
COPS2Affinity Capture-Westernphysical19268428
UBCAffinity Capture-Westernphysical19268428
CSNK2A2Biochemical Activityphysical15218032
UBCAffinity Capture-Westernphysical21817095