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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for A2M (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001869 negative regulation of complement activation, lectin pathway IDA GO:0002576 platelet degranulation TAS GO:0007264 small GTPase mediated signal transduction TAS GO:0007596 blood coagulation TAS GO:0007597 blood coagulation, intrinsic pathway TAS GO:0030168 platelet activation TAS GO:0051056 regulation of small GTPase mediated signal transduction TAS cellular_component GO:0005576 extracellular region NAS GO:0005576 extracellular region TAS GO:0005615 extracellular space IEA GO:0005829 cytosol TAS GO:0031093 platelet alpha granule lumen TAS molecular_function GO:0004866 endopeptidase inhibitor activity IEA GO:0004867 serine-type endopeptidase inhibitor activity IDA GO:0005515 protein binding IPI GO:0019838 growth factor binding IDA GO:0019899 enzyme binding IPI GO:0019959 interleukin-8 binding IPI GO:0019966 interleukin-1 binding IDA GO:0043120 tumor necrosis factor binding IDA

Protein-protein interaction details for A2M (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID KLK13 Reconstituted Complex physical 14687906 CPB2 Reconstituted Complex physical 8662763 ADAMTS1 Affinity Capture-Western physical 10373500 LRP1 Co-crystal Structure physical 10652313 PAEP Reconstituted Complex physical 11023837 PAEP Co-purification physical 11023837 LEP Reconstituted Complex physical 9724081 B2M Reconstituted Complex physical 10731476 MMP2 Reconstituted Complex physical 9344465 LCAT Affinity Capture-Western physical 11435418 LCAT Reconstituted Complex physical 11435418 AMBP Affinity Capture-Western physical 7519849 NGF Reconstituted Complex physical 10681572 AMBP Affinity Capture-Western physical 1697852 KLK3 Affinity Capture-Western physical 1702714 APOE Affinity Capture-Western physical 9831625 APOE Reconstituted Complex physical 9831625 HSPA5 Reconstituted Complex physical 12194978 IL10 Reconstituted Complex physical 10714547 IL4 Reconstituted Complex physical 10714547 GRB2 Two-hybrid physical 18624398 GEM Two-hybrid physical 18624398 CDC42 Two-hybrid physical 18624398 HMOX2 Two-hybrid physical 21900206 NUDT21 Two-hybrid physical 21900206 UFD1L Two-hybrid physical 21900206 RAP1B Two-hybrid physical 21900206 SEPT8 Two-hybrid physical 21900206 RPP14 Two-hybrid physical 21900206 H2AFX Two-hybrid physical 21900206 TGIF1 Two-hybrid physical 21900206 TK1 Two-hybrid physical 21900206 CDKN1A Two-hybrid physical 21900206 TNFRSF14 Two-hybrid physical 21900206 SMN1 Two-hybrid physical 21900206 TTR Two-hybrid physical 21900206 CDK2AP2 Two-hybrid physical 21900206 ANXA7 Two-hybrid physical 21900206 TSC22D1 Two-hybrid physical 21900206 C11orf58 Two-hybrid physical 21900206