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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for AKT1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000060 protein import into nucleus, translocation IMP GO:0001893 maternal placenta development IEA GO:0001934 positive regulation of protein phosphorylation IDA GO:0005975 carbohydrate metabolic process IEA GO:0005978 glycogen biosynthetic process IEA GO:0005979 regulation of glycogen biosynthetic process IMP GO:0006006 glucose metabolic process IEA GO:0006412 translation IEA GO:0006417 regulation of translation IEA GO:0006464 protein modification process TAS GO:0006468 protein phosphorylation IDA GO:0006469 negative regulation of protein kinase activity IEA GO:0006469 negative regulation of protein kinase activity IMP GO:0006469 negative regulation of protein kinase activity ISS GO:0006809 nitric oxide biosynthetic process TAS GO:0006810 transport IEA GO:0006915 apoptosis TAS GO:0006916 anti-apoptosis TAS GO:0006924 activation-induced cell death of T cells IMP GO:0006954 inflammatory response IEA GO:0007165 signal transduction IEA GO:0007165 signal transduction TAS GO:0007186 G-protein coupled receptor protein signaling pathway TAS GO:0007275 multicellular organismal development IEA GO:0007281 germ cell development IEA GO:0007399 nervous system development IEA GO:0007596 blood coagulation TAS GO:0008283 cell proliferation TAS GO:0008286 insulin receptor signaling pathway IEA GO:0008286 insulin receptor signaling pathway IMP GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0008629 induction of apoptosis by intracellular signals TAS GO:0008633 activation of pro-apoptotic gene products TAS GO:0008637 apoptotic mitochondrial changes IEA GO:0008643 carbohydrate transport IEA GO:0009408 response to heat TAS GO:0009725 response to hormone stimulus IEA GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport IMP GO:0010765 positive regulation of sodium ion transport IEA GO:0010907 positive regulation of glucose metabolic process IMP GO:0010975 regulation of neuron projection development IEA GO:0010975 regulation of neuron projection development ISS GO:0015758 glucose transport IEA GO:0016070 RNA metabolic process TAS GO:0016071 mRNA metabolic process TAS GO:0016310 phosphorylation IDA GO:0016567 protein ubiquitination IEA GO:0018105 peptidyl-serine phosphorylation IDA GO:0018105 peptidyl-serine phosphorylation IEA GO:0030030 cell projection organization IEA GO:0030154 cell differentiation TAS GO:0030163 protein catabolic process IEA GO:0030168 platelet activation TAS GO:0030307 positive regulation of cell growth IDA GO:0030307 positive regulation of cell growth IEA GO:0030334 regulation of cell migration IEA GO:0030334 regulation of cell migration IMP GO:0030334 regulation of cell migration TAS GO:0031018 endocrine pancreas development TAS GO:0031295 T cell costimulation TAS GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S IDA GO:0031999 negative regulation of fatty acid beta-oxidation IMP GO:0032094 response to food IEA GO:0032270 positive regulation of cellular protein metabolic process IEA GO:0032270 positive regulation of cellular protein metabolic process ISS GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA GO:0032869 cellular response to insulin stimulus IMP GO:0032869 cellular response to insulin stimulus ISS GO:0032880 regulation of protein localization IEA GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA GO:0034405 response to fluid shear stress IMP GO:0035556 intracellular signal transduction IDA GO:0042593 glucose homeostasis IEA GO:0042640 anagen IEA GO:0043066 negative regulation of apoptosis IDA GO:0043066 negative regulation of apoptosis NAS GO:0043154 negative regulation of caspase activity ISS GO:0043536 positive regulation of blood vessel endothelial cell migration IDA GO:0045429 positive regulation of nitric oxide biosynthetic process IMP GO:0045600 positive regulation of fat cell differentiation IMP GO:0045725 positive regulation of glycogen biosynthetic process IMP GO:0045725 positive regulation of glycogen biosynthetic process NAS GO:0045768 positive regulation of anti-apoptosis ISS GO:0045792 negative regulation of cell size IEA GO:0045884 regulation of survival gene product expression IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046209 nitric oxide metabolic process TAS GO:0046326 positive regulation of glucose import IMP GO:0046329 negative regulation of JNK cascade IEA GO:0046777 protein autophosphorylation TAS GO:0046889 positive regulation of lipid biosynthetic process IMP GO:0048009 insulin-like growth factor receptor signaling pathway IMP GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0050999 regulation of nitric-oxide synthase activity TAS GO:0051000 positive regulation of nitric-oxide synthase activity IMP GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA GO:0051146 striated muscle cell differentiation IEA GO:0060644 mammary gland epithelial cell differentiation TAS GO:0060709 glycogen cell development involved in embryonic placenta development IEA GO:0060716 labyrinthine layer blood vessel development IEA GO:0070141 response to UV-A IDA GO:0071363 cellular response to growth factor stimulus IEA GO:0090004 positive regulation of establishment of protein localization in plasma membrane IMP GO:0090201 negative regulation of release of cytochrome c from mitochondria ISS GO:2001047 regulation of G1/S transition checkpoint TAS cellular_component GO:0005624 membrane fraction IDA GO:0005625 soluble fraction IEA GO:0005634 nucleus IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm IEA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005737 cytoplasm ISS GO:0005737 cytoplasm TAS GO:0005819 spindle IEA GO:0005829 cytosol IDA GO:0005829 cytosol IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005886 plasma membrane IEA GO:0005886 plasma membrane TAS GO:0015630 microtubule cytoskeleton IDA GO:0030027 lamellipodium IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity TAS GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity IEA GO:0004674 protein serine/threonine kinase activity TAS GO:0005080 protein kinase C binding IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IC GO:0005524 ATP binding IDA GO:0005524 ATP binding IEA GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA GO:0016301 kinase activity IDA GO:0019899 enzyme binding IEA GO:0019899 enzyme binding ISS GO:0030235 nitric-oxide synthase regulator activity IMP GO:0042802 identical protein binding IPI GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA

Protein-protein interaction details for AKT1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID PLXNA1 Two-hybrid physical 15187088 AR Reconstituted Complex physical 11404460 AR Affinity Capture-Western physical 11404460 BRCA1 Reconstituted Complex physical 10542266 FANCA Two-hybrid physical 14499622 PLXNA1 Reconstituted Complex physical 15187088 PAK1 Reconstituted Complex physical 14749719 ARHGAP29 Two-hybrid physical 14749388 AKTIP Affinity Capture-Western physical 14749367 AKTIP Reconstituted Complex physical 14749367 AKTIP Reconstituted Complex physical 14749367 TRIB3 Reconstituted Complex physical 12791994 TRIB3 Affinity Capture-Western physical 12791994 HSP90AA1 Affinity Capture-Western physical 12586360 IRAK1 Affinity Capture-Western physical 11976320 IMPDH2 Two-hybrid physical 10930578 IMPDH2 Reconstituted Complex physical 10930578 IMPDH2 Affinity Capture-Western physical 10930578 BRAF Affinity Capture-Western physical 10869359 BRAF Affinity Capture-Western physical 10869359 BRAF Biochemical Activity physical 10869359 HSPB1 Affinity Capture-Western physical 11042204 MAPKAPK2 Affinity Capture-Western physical 11042204 MAPK14 Affinity Capture-Western physical 11042204 MAPKAPK2 Affinity Capture-Western physical 11042204 MAPK14 Biochemical Activity physical 11042204 CHN2 Reconstituted Complex physical 11278894 KTN1 Two-hybrid physical 11162552 TCL1A Affinity Capture-Western physical 11707444 MTCP1 Affinity Capture-Western physical 11707444 KRT10 Affinity Capture-Western physical 11585925 KRT10 Two-hybrid physical 11585925 RAF1 Biochemical Activity physical 10576742 RAF1 Affinity Capture-Western physical 10576742 MTOR Reconstituted Complex physical 15718470 SMAD2 Affinity Capture-Western physical 16362038 SMAD3 Affinity Capture-Western physical 16362038 SMAD4 Affinity Capture-Western physical 16362038 SMAD7 Affinity Capture-Western physical 16362038 RPS6KB1 Co-purification physical 15149849 TSC1 Affinity Capture-Western physical 15342917 TSC2 Affinity Capture-Western physical 12167664 TSC2 Affinity Capture-Western physical 15342917 MAPKAP1 Affinity Capture-Western physical 16962653 RICTOR Reconstituted Complex physical 15718470 BAD Reconstituted Complex physical 11500364 MTOR Reconstituted Complex physical 10910062 MTOR Protein-peptide physical 14970221 GSK3B Reconstituted Complex physical 16009706 HSP90AA1 Affinity Capture-Western physical 15843522 TERT Affinity Capture-Western physical 15843522 TSC1 Affinity Capture-Western physical 12167664 TSC2 Reconstituted Complex physical 12167664 TSC2 Affinity Capture-Western physical 12167664 CARHSP1 Reconstituted Complex physical 15910284 PAK6 Reconstituted Complex physical 11773441 ARHGAP32 Biochemical Activity physical 12446789 PRKCQ Reconstituted Complex physical 11410591 PRKCQ Affinity Capture-Western physical 11410591 THEM4 Affinity Capture-Western physical 11598301 CDKN1B Biochemical Activity physical 12042314 CDKN1B Affinity Capture-Western physical 12042314 NR4A1 Affinity Capture-Western physical 11274386 NR4A1 Biochemical Activity physical 11274386 MAP3K11 Affinity Capture-Western physical 12458207 MAP3K11 Reconstituted Complex physical 12458207 MAP2K4 Affinity Capture-Western physical 11707464 MAP2K4 Affinity Capture-Western physical 11707464 MAP2K4 Biochemical Activity physical 11707464 PRKCZ Affinity Capture-Western physical 10085094 MTCP1 Affinity Capture-Western physical 10983986 TCL1A Affinity Capture-Western physical 10983986 TCL1B Affinity Capture-Western physical 10983986 HSP90AA1 Affinity Capture-Western physical 10995457 HSP90AB1 Affinity Capture-Western physical 10995457 GAB2 Affinity Capture-Western physical 11782427 GAB2 Biochemical Activity physical 11782427 CHUK Affinity Capture-Western physical 10485710 CHUK Biochemical Activity physical 10485710 TCL1A Affinity Capture-Western physical 12009899 TCL1A Reconstituted Complex physical 12009899 PDPK1 Affinity Capture-Western physical 11825911 ILK Affinity Capture-Western physical 11825911 MAPK8IP1 Affinity Capture-Western physical 12194869 PKN2 Two-hybrid physical 10926925 PKN2 Affinity Capture-Western physical 10926925 MAP3K8 Affinity Capture-Western physical 12138205 MAP3K8 Affinity Capture-Western physical 12138205 MAP3K8 Biochemical Activity physical 12138205 YWHAZ Affinity Capture-Western physical 11956222 YWHAZ Reconstituted Complex physical 11956222 YWHAZ Biochemical Activity physical 11956222 CHUK Affinity Capture-Western physical 10485711 ILK Biochemical Activity physical 9736715 ARFIP2 Two-hybrid physical 9312003 ILK Affinity Capture-Western physical 11313365 PDPK1 Affinity Capture-Western physical 11313365 IRS1 Affinity Capture-Western physical 10497255 BRCA1 Affinity Capture-Western physical 19074868 BRCA1 Reconstituted Complex physical 19074868 BRCA1 Biochemical Activity physical 19074868 NPM1 Reconstituted Complex physical 18931307 NPM1 Reconstituted Complex physical 18931307 NPM1 Affinity Capture-Western physical 18931307 NPM1 Affinity Capture-Western physical 18931307 STUB1 Affinity Capture-Western physical 18292230 UBC Affinity Capture-Western physical 18292230 MARK2 Affinity Capture-Western physical 18292230 MARK2 Affinity Capture-Western physical 18292230 NF2 Affinity Capture-Western physical 17891137 NF2 Affinity Capture-Western physical 17891137 NF2 Reconstituted Complex physical 17891137 NF2 Reconstituted Complex physical 17891137 PLXNB1 Affinity Capture-Western physical 19805522 PIAS1 Two-hybrid physical 17533377 PIAS2 Two-hybrid physical 17533377 USP8 Affinity Capture-Western physical 17210635 HDAC3 Affinity Capture-Western physical 20026773 IKBKG Reconstituted Complex physical 20098747 MXD1 Affinity Capture-Western physical 19526459 MXD1 Reconstituted Complex physical 19526459 MXD1 Reconstituted Complex physical 19526459 MXD1 Affinity Capture-Western physical 19526459 MXD1 Biochemical Activity physical 19526459 CHUK Affinity Capture-Western physical 15800029 NCOR2 Biochemical Activity physical 16613989 NCOR2 Reconstituted Complex physical 16613989 SMARCB1 Affinity Capture-Western physical 16568092 SMARCB1 Affinity Capture-Western physical 16568092 ACTA1 Affinity Capture-Western physical 16568092 SMARCC1 Affinity Capture-Western physical 16568092 SMARCC2 Affinity Capture-Western physical 16568092 SMARCB1 Biochemical Activity physical 16568092 SMARCC1 Biochemical Activity physical 16568092 SMARCC1 Reconstituted Complex physical 16568092 SMARCB1 Reconstituted Complex physical 16568092 MDM2 Affinity Capture-Western physical 12145204 EZH2 Affinity Capture-Western physical 16224021 EZH2 Affinity Capture-Western physical 16224021 EZH2 Biochemical Activity physical 16224021 PPA1 Affinity Capture-Western physical 16186112 PPA1 Affinity Capture-Western physical 16186112 FOXO1 Biochemical Activity physical 16076959 XIAP Affinity Capture-Western physical 14645242 XIAP Biochemical Activity physical 14645242 HSPA4 Affinity Capture-Western physical 12750378 UBC Affinity Capture-Western physical 12750378 NOTCH1 Biochemical Activity physical 18440314 HSP90AA1 Affinity Capture-Western physical 12176997 CDC37 Affinity Capture-Western physical 12176997 CDC37 Affinity Capture-Western physical 12176997 IKBKB Affinity Capture-Western physical 15856005 IKBKB Affinity Capture-Western physical 15856005 EP300 Affinity Capture-Western physical 18182168 MDM2 Biochemical Activity physical 11923280 UBC Affinity Capture-Western physical 11923280 MDM2 Affinity Capture-Western physical 11715018 MDM2 Biochemical Activity physical 11715018 SETDB1 Two-hybrid physical 17577629 SETDB1 Reconstituted Complex physical 17577629 SETDB1 Affinity Capture-Western physical 17577629 FANCA Biochemical Activity physical 11855836 FANCA Affinity Capture-Western physical 11855836 CREBBP Reconstituted Complex physical 19995607 CREBBP Biochemical Activity physical 19995607 GSK3A Biochemical Activity physical 19995607 GSK3B Biochemical Activity physical 19995607 HSP90AA1 Affinity Capture-Western physical 21767636 STUB1 Affinity Capture-Western physical 21767636 DNMT1 Biochemical Activity physical 21151116 DNMT1 Affinity Capture-Western physical 21151116 DNMT1 Affinity Capture-Western physical 21151116 DNMT1 Reconstituted Complex physical 21151116 SKP2 Affinity Capture-Western physical 19270694 SKP2 Affinity Capture-Western physical 19270694 SKP2 Reconstituted Complex physical 19270694 SKP2 Biochemical Activity physical 19270694 SKP2 Co-localization physical 19270694 MDM2 Affinity Capture-Western physical 21930127 MDM2 Affinity Capture-Western physical 21930127 PA2G4 Affinity Capture-Western physical 21930127 PA2G4 Affinity Capture-Western physical 21930127 ERBB3 Affinity Capture-Western physical 21930127 TRIM13 Affinity Capture-Western physical 21333377 UBC Affinity Capture-Western physical 21333377 CTBP1 Affinity Capture-Western physical 20361981 TTC3 Affinity Capture-Western physical 20059950 TTC3 Biochemical Activity physical 20059950 TTC3 Reconstituted Complex physical 20059950 UBC Affinity Capture-Western physical 20059950 ESR1 Biochemical Activity physical 11139588 CALM1 Reconstituted Complex physical 15840729 CALM1 Affinity Capture-Western physical 15840729 UBC Affinity Capture-Western physical 21464312 MTOR Biochemical Activity physical 21045808 NCOA4 Two-hybrid physical 18624398 APOH Two-hybrid physical 18624398 ASXL1 Two-hybrid physical 18624398 BPGM Two-hybrid physical 18624398 COMMD1 Two-hybrid physical 18624398 DNAJB1 Two-hybrid physical 18624398 PPL Two-hybrid physical 18624398 ASXL1 Affinity Capture-Western physical 18624398 UBC Affinity Capture-Western physical 21045808 PI4K2B Two-hybrid physical 18624398 ZHX1 Two-hybrid physical 21900206 EEF1G Two-hybrid physical 21900206 DCTN1 Two-hybrid physical 21900206 IKBKG Affinity Capture-Western physical 20837477 PPP2CA Affinity Capture-Western physical 18191226 PPP2CA Reconstituted Complex physical 18191226 ARRB2 Affinity Capture-Western physical 18191226 ARRB2 Reconstituted Complex physical 18191226 MXD1 Biochemical Activity physical 18451027 COMMD1 Affinity Capture-Western physical 20237237 UBC Affinity Capture-Western physical 20336670 PHLPP1 Affinity Capture-Western physical 20605778 FKBP5 Affinity Capture-Western physical 20605778 PPP3CA Affinity Capture-Western physical 20605778 PTEN Affinity Capture-Western physical 20605778 SKP2 Affinity Capture-Western physical 21358672