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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ALOX5 (Homo sapiens)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0002526acute inflammatory responseIEA
GO:0002540leukotriene production involved in inflammatory responseIEA
GO:0006691leukotriene metabolic processIEA
GO:0006691leukotriene metabolic processTAS
GO:0006692prostanoid metabolic processTAS
GO:0007584response to nutrientIEA
GO:0019233sensory perception of painIEA
GO:0019369arachidonic acid metabolic processIEA
GO:0019370leukotriene biosynthetic processIDA
GO:0019370leukotriene biosynthetic processTAS
GO:0019372lipoxygenase pathwayIEA
GO:0045907positive regulation of vasoconstrictionIEA
GO:0055093response to hyperoxiaIEA
cellular_component
GO:0005625soluble fractionIEA
GO:0005634nucleusIEA
GO:0005635nuclear envelopeIDA
GO:0005641nuclear envelope lumenIDA
GO:0005737cytoplasmIEA
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0016020membraneIEA
GO:0016363nuclear matrixIDA
GO:0030425dendriteIEA
GO:0031965nuclear membraneIDA
GO:0042383sarcolemmaIEA
molecular_function
GO:0004051arachidonate 5-lipoxygenase activityIDA
GO:0004051arachidonate 5-lipoxygenase activityIEA
GO:0004051arachidonate 5-lipoxygenase activityTAS
GO:0005506iron ion bindingIDA
GO:0005506iron ion bindingIEA
GO:0005515protein bindingIPI
GO:0016165lipoxygenase activityIEA
GO:0016491oxidoreductase activityIEA
GO:0046872metal ion bindingIEA

Protein-protein interaction details for ALOX5 (Homo sapiens)
(Information is obtained from BioGRID)
Interacting human proteinExperimentTypePubMed ID
COTL1Two-hybridphysical11297527
TGFBRAP1Two-hybridphysical10051563
COTL1P1Two-hybridphysical10051563
GRB2Reconstituted Complexphysical8585605
GRB2Reconstituted Complexphysical7929073
COTL1Reconstituted Complexphysical11297527
COTL1Affinity Capture-Westernphysical11297527