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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for APAF1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006915 apoptosis TAS GO:0006919 activation of caspase activity IDA GO:0006919 activation of caspase activity NAS GO:0006952 defense response IEA GO:0007399 nervous system development TAS GO:0008629 induction of apoptosis by intracellular signals TAS GO:0008635 activation of caspase activity by cytochrome c IDA GO:0008635 activation of caspase activity by cytochrome c TAS GO:0042981 regulation of apoptosis IEA GO:0042981 regulation of apoptosis TAS cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005794 Golgi apparatus IDA GO:0005829 cytosol TAS GO:0043293 apoptosome IDA molecular_function GO:0000166 nucleotide binding TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008656 caspase activator activity NAS

Protein-protein interaction details for APAF1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID APIP Reconstituted Complex physical 15262985 APIP Affinity Capture-Western physical 15262985 CASP9 Reconstituted Complex physical 15262985 APIP Two-hybrid physical 15262985 CASP9 Affinity Capture-Western physical 9390557 NLRP1 Affinity Capture-Western physical 11113115 CASP9 Affinity Capture-Western physical 11113115 NLRP1 Co-purification physical 11113115 HSPA4 Affinity Capture-Western physical 10934467 HSP90AA1 Affinity Capture-Western physical 10934467 HSPA4 Reconstituted Complex physical 10934467 HSPA4 Co-purification physical 10934467 CASP9 Affinity Capture-Western physical 9539746 CASP4 Affinity Capture-Western physical 9539746 CASP8 Affinity Capture-Western physical 9539746 BCL2L1 Affinity Capture-Western physical 9539746 CASP9 Affinity Capture-Western physical 9488720 BCL2L1 Affinity Capture-Western physical 9488720 CYCS Affinity Capture-Western physical 9267021 AVEN Affinity Capture-Western physical 10949025 TRIAP1 Affinity Capture-Western physical 15735003