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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for APP (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000085 G2 phase of mitotic cell cycle ISS GO:0001967 suckling behavior IEA GO:0002218 activation of innate immune response TAS GO:0002576 platelet degranulation TAS GO:0006378 mRNA polyadenylation ISS GO:0006417 regulation of translation ISS GO:0006468 protein phosphorylation ISS GO:0006878 cellular copper ion homeostasis ISS GO:0006897 endocytosis ISS GO:0006917 induction of apoptosis IEA GO:0007155 cell adhesion IEA GO:0007176 regulation of epidermal growth factor-activated receptor activity ISS GO:0007219 Notch signaling pathway IEA GO:0007409 axonogenesis ISS GO:0007596 blood coagulation TAS GO:0007617 mating behavior ISS GO:0007626 locomotory behavior ISS GO:0008088 axon cargo transport ISS GO:0008219 cell death IEA GO:0008344 adult locomotory behavior ISS GO:0008542 visual learning ISS GO:0010468 regulation of gene expression IEA GO:0016199 axon midline choice point recognition ISS GO:0016322 neuron remodeling ISS GO:0016358 dendrite development ISS GO:0030168 platelet activation TAS GO:0030198 extracellular matrix organization ISS GO:0030900 forebrain development IEA GO:0031175 neuron projection development ISS GO:0035235 ionotropic glutamate receptor signaling pathway ISS GO:0040014 regulation of multicellular organism growth ISS GO:0045087 innate immune response TAS GO:0045665 negative regulation of neuron differentiation IEA GO:0045931 positive regulation of mitotic cell cycle ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048669 collateral sprouting in absence of injury ISS GO:0050803 regulation of synapse structure and activity ISS GO:0050885 neuromuscular process controlling balance IEA GO:0051124 synaptic growth at neuromuscular junction IEA GO:0051402 neuron apoptosis IMP GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IEA cellular_component GO:0005576 extracellular region TAS GO:0005737 cytoplasm IDA GO:0005737 cytoplasm ISS GO:0005794 Golgi apparatus IDA GO:0005794 Golgi apparatus ISS GO:0005829 cytosol TAS GO:0005886 plasma membrane IDA GO:0005887 integral to plasma membrane TAS GO:0005905 coated pit IEA GO:0009986 cell surface IDA GO:0016021 integral to membrane IEA GO:0016021 integral to membrane ISS GO:0019717 synaptosome IEA GO:0030424 axon ISS GO:0031093 platelet alpha granule lumen TAS GO:0031410 cytoplasmic vesicle IEA GO:0031594 neuromuscular junction IEA GO:0035253 ciliary rootlet IEA GO:0043197 dendritic spine IDA GO:0043198 dendritic shaft IDA GO:0043231 intracellular membrane-bounded organelle IDA GO:0045177 apical part of cell IEA GO:0045202 synapse IDA GO:0048471 perinuclear region of cytoplasm IEA GO:0051233 spindle midzone IEA molecular_function GO:0003677 DNA binding ISS GO:0004867 serine-type endopeptidase inhibitor activity IDA GO:0004867 serine-type endopeptidase inhibitor activity IEA GO:0005102 receptor binding IPI GO:0005488 binding IEA GO:0005515 protein binding IPI GO:0008201 heparin binding IEA GO:0016504 peptidase activator activity IEA GO:0030414 peptidase inhibitor activity IEA GO:0033130 acetylcholine receptor binding IPI GO:0042802 identical protein binding IPI GO:0046872 metal ion binding IEA GO:0051425 PTB domain binding IPI

Protein-protein interaction details for APP (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID APPBP2 Two-hybrid physical 9843960 CLSTN1 Affinity Capture-Western physical 15037614 APBB2 Affinity Capture-Western physical 14527950 CLSTN1 Affinity Capture-Western physical 12972431 APBA2 Affinity Capture-Western physical 12972431 APBA2 Affinity Capture-Western physical 12972431 FBLN1 Two-hybrid physical 11238726 FBLN1 Reconstituted Complex physical 11238726 FBLN1 Affinity Capture-Western physical 11238726 APBA1 Affinity Capture-Western physical 12196555 APBA2 Affinity Capture-Western physical 12196555 APBA3 Affinity Capture-Western physical 12196555 APBA1 Reconstituted Complex physical 12196555 APBA2 Reconstituted Complex physical 12196555 APBA3 Reconstituted Complex physical 12196555 DAB2 Reconstituted Complex physical 11247302 CALR Affinity Capture-Western physical 11378243 COL25A1 Reconstituted Complex physical 11927537 COL25A1 Co-localization physical 11927537 HSD17B10 Two-hybrid physical 9338779 HSD17B10 Reconstituted Complex physical 9338779 HSD17B10 Affinity Capture-Western physical 9338779 CAV1 Co-fractionation physical 9553108 CAV1 Protein-RNA physical 9553108 APBA2 Two-hybrid physical 9890987 APBA2 Reconstituted Complex physical 9890987 KLC1 Reconstituted Complex physical 11144355 NCSTN Affinity Capture-Western physical 10993067 APPBP2 Reconstituted Complex physical 9843960 BGN Reconstituted Complex physical 7793988 APBA1 Reconstituted Complex physical 8887653 APBB1 Reconstituted Complex physical 8887653 APBB1 Reconstituted Complex physical 8887653 APBA1 Reconstituted Complex physical 8887653 APBB1 Affinity Capture-Western physical 8887653 APBA1 Affinity Capture-Western physical 8887653 SNCA Reconstituted Complex physical 9163350 SNCB Reconstituted Complex physical 9163350 DAB1 Reconstituted Complex physical 10460257 ACHE Reconstituted Complex physical 12427014 SHC1 Reconstituted Complex physical 11877420 SHC1 Affinity Capture-Western physical 11877420 APBB1 Reconstituted Complex physical 9045663 APBB1 Affinity Capture-Western physical 8855266 NAE1 Reconstituted Complex physical 8626687 NAE1 Affinity Capture-Western physical 8626687 GSN Reconstituted Complex physical 10329371 GSN Affinity Capture-Western physical 10329371 APBA3 Two-hybrid physical 10049767 APBA3 Reconstituted Complex physical 10049767 BLMH Reconstituted Complex physical 10973933 BLMH Co-fractionation physical 10973933 APBB3 Reconstituted Complex physical 10081969 APBB1 Reconstituted Complex physical 10081969 APBB1 Two-hybrid physical 9837937 APBB1 Reconstituted Complex physical 9837937 HGS Reconstituted Complex physical 19019082 SET Protein-peptide physical 16162853 PARK2 Affinity Capture-Western physical 19610108 STUB1 Affinity Capture-Western physical 17317785 STUB1 Affinity Capture-Western physical 17317785 UBC Affinity Capture-Western physical 17317785 UBC Affinity Capture-Western physical 17317785 HSPD1 Affinity Capture-Western physical 17317785 HSPA4 Affinity Capture-Western physical 17317785 HSP90AA1 Affinity Capture-Western physical 17317785 SYVN1 Affinity Capture-Western physical 20237263 UBC Reconstituted Complex physical 20237263 SYVN1 Biochemical Activity physical 20237263 UBC Affinity Capture-MS physical 21987572