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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for ATM (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000077 DNA damage checkpoint IEA GO:0000724 double-strand break repair via homologous recombination TAS GO:0001666 response to hypoxia IEA GO:0001756 somitogenesis IEA GO:0002331 pre-B cell allelic exclusion IEA GO:0002331 pre-B cell allelic exclusion ISS GO:0006281 DNA repair IEA GO:0006281 DNA repair TAS GO:0006302 double-strand break repair TAS GO:0006974 response to DNA damage stimulus IMP GO:0006975 DNA damage induced protein phosphorylation IDA GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS GO:0007050 cell cycle arrest IMP GO:0007094 mitotic cell cycle spindle assembly checkpoint IMP GO:0007131 reciprocal meiotic recombination TAS GO:0007165 signal transduction TAS GO:0007292 female gamete generation IEA GO:0007420 brain development IEA GO:0007507 heart development IEA GO:0008219 cell death IEA GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis IEA GO:0010212 response to ionizing radiation IDA GO:0010212 response to ionizing radiation IEA GO:0018105 peptidyl-serine phosphorylation IDA GO:0030889 negative regulation of B cell proliferation IMP GO:0031572 G2/M transition DNA damage checkpoint IMP GO:0042159 lipoprotein catabolic process IEA GO:0043065 positive regulation of apoptosis IMP GO:0043066 negative regulation of apoptosis IEA GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP GO:0043525 positive regulation of neuron apoptosis IEA GO:0046777 protein autophosphorylation IDA GO:0046777 protein autophosphorylation IEA GO:0051726 regulation of cell cycle IEA GO:0071044 histone mRNA catabolic process IDA GO:0071480 cellular response to gamma radiation IDA GO:0090399 replicative senescence IMP cellular_component GO:0000781 chromosome, telomeric region IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm IEA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IEA GO:0005819 spindle IEA GO:0016023 cytoplasmic membrane-bounded vesicle IEA molecular_function GO:0000166 nucleotide binding IEA GO:0003677 DNA binding IEA GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity IEA GO:0004677 DNA-dependent protein kinase activity IDA GO:0005488 binding IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016303 1-phosphatidylinositol-3-kinase activity IMP GO:0032403 protein complex binding IDA GO:0035174 histone serine kinase activity IEA GO:0046983 protein dimerization activity IDA GO:0047485 protein N-terminus binding IDA

Protein-protein interaction details for ATM (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID ABL1 Two-hybrid physical 9168117 RBBP8 Affinity Capture-Western physical 10910365 BRCA1 Affinity Capture-Western physical 10866324 BRCA1 Reconstituted Complex physical 10866324 CREB1 Affinity Capture-Western physical 15073328 RBBP8 Reconstituted Complex physical 10910365 FANCD2 Reconstituted Complex physical 12086603 FANCD2 Affinity Capture-Western physical 12086603 SMC1A Affinity Capture-Western physical 11877376 SMC1A Reconstituted Complex physical 11877376 TP53 Reconstituted Complex physical 15632067 BLM Co-purification physical 10783165 TP53 Reconstituted Complex physical 15159397 TP53 Reconstituted Complex physical 9843217 TP53 Phenotypic Enhancement genetic 9135004 BLM Reconstituted Complex physical 12034743 BLM Affinity Capture-Western physical 12034743 AP1B1 Protein-peptide physical 10608806 AP2A2 Protein-peptide physical 10608806 ATM Protein-peptide physical 10608806 ATR Protein-peptide physical 10608806 PRKDC Protein-peptide physical 10608806 BRCA1 Protein-peptide physical 10608806 CHEK1 Protein-peptide physical 10608806 E4F1 Protein-peptide physical 10608806 EIF4EBP1 Protein-peptide physical 10608806 LIG4 Protein-peptide physical 10608806 MRE11A Protein-peptide physical 10608806 NBN Protein-peptide physical 10608806 PTS Protein-peptide physical 10608806 RAD17 Protein-peptide physical 10608806 RBBP8 Protein-peptide physical 10608806 TP53 Protein-peptide physical 10608806 WRN Protein-peptide physical 10608806 BRCA1 Affinity Capture-Western physical 10550055 BRCA1 Reconstituted Complex physical 10550055 BRCA1 Reconstituted Complex physical 11114888 BRCA1 Reconstituted Complex physical 11016625 BRCA1 Reconstituted Complex physical 11278964 BRCA2 Reconstituted Complex physical 15199141 TP53BP1 Reconstituted Complex physical 12447390 ABL1 Affinity Capture-Western physical 10212258 ABL1 Affinity Capture-Western physical 10212258 BRCA1 Co-purification physical 10783165 FANCD2 Two-hybrid physical 14499622 MLH1 Co-purification physical 10783165 MRE11A Co-purification physical 10783165 MSH2 Co-purification physical 10783165 MSH6 Co-purification physical 10783165 NBN Co-purification physical 10783165 RAD50 Co-purification physical 10783165 RAD51 Affinity Capture-Western physical 10212258 RAD51 Affinity Capture-Western physical 10212258 RFC1 Co-purification physical 10783165 MCM2 Biochemical Activity physical 15210935 MDC1 Affinity Capture-Western physical 14519663 TP53BP1 Biochemical Activity physical 12697768 TERF1 Affinity Capture-Western physical 11375976 TERF1 Affinity Capture-Western physical 11375976 ABL1 Affinity Capture-Western physical 11375976 ABL1 Affinity Capture-Western physical 11375976 TERF1 Biochemical Activity physical 11375976 PEX5 Two-hybrid physical 10567403 RHEB Reconstituted Complex physical 15854902 RHEB Affinity Capture-Western physical 15854902 TP53 Biochemical Activity physical 9843217 PRKDC Affinity Capture-Western physical 10464290 PRKDC Affinity Capture-Western physical 10464290 RAD17 Affinity Capture-Western physical 11418864 ABL1 Affinity Capture-Western physical 9168117 ABL1 Reconstituted Complex physical 9168117 RRM2B Affinity Capture-Western physical 19015526 RRM2B Affinity Capture-Western physical 19015526 XPC Co-localization physical 19805520 SMARCB1 Affinity Capture-Western physical 19805520 SMARCB1 Affinity Capture-Western physical 19805520 HUWE1 Affinity Capture-Western physical 17478428 USP34 Affinity Capture-Western physical 17478428 MED1 Affinity Capture-Western physical 17478428 FANCI Affinity Capture-Western physical 17478428 SMC3 Affinity Capture-Western physical 17478428 TAOK3 Affinity Capture-Western physical 17478428 TDP1 Affinity Capture-Western physical 17478428 BRCA1 Affinity Capture-Western physical 17478428 CDC6 Reconstituted Complex physical 20048340 TTI1 Affinity Capture-Western physical 20427287 TELO2 Affinity Capture-Western physical 20427287 ATR Biochemical Activity physical 17124492 TP53BP1 Biochemical Activity physical 18996087 CXXC5 Reconstituted Complex physical 19557330 DCLRE1A Affinity Capture-Western physical 18848520 MCPH1 Co-localization physical 16872911 DDX1 Affinity Capture-Western physical 18710941 DDX1 Reconstituted Complex physical 18710941 TELO2 Affinity Capture-Western physical 20801936 VHL Affinity Capture-Western physical 16678111 HNRNPUL1 Affinity Capture-Western physical 18480432 MYST1 Two-hybrid physical 15923642 MYST1 Two-hybrid physical 15923642 MYST1 Affinity Capture-Western physical 15923642 MYST1 Affinity Capture-Western physical 15923642 MYST1 Reconstituted Complex physical 15923642 MYST1 Reconstituted Complex physical 15923642 ATF2 Biochemical Activity physical 15916964 FOXO3 Affinity Capture-Western physical 18344987 H2AFX Affinity Capture-Western physical 18344987 BRCA1 Affinity Capture-Western physical 18344987 RAD17 Affinity Capture-Western physical 18344987 FOXO3 Affinity Capture-Western physical 18344987 H2AFX Affinity Capture-Western physical 18344987 FOXO3 Reconstituted Complex physical 18344987 HDAC1 Reconstituted Complex physical 10531300 HDAC1 Affinity Capture-Western physical 10531300 CHEK2 Biochemical Activity physical 15064416 TP53 Biochemical Activity physical 15064416 TP53 Reconstituted Complex physical 15064416 CHEK2 Reconstituted Complex physical 15064416 ABL1 Biochemical Activity physical 17409407 TP53 Biochemical Activity physical 17409407 NBN Affinity Capture-Western physical 17507690 BMI1 Affinity Capture-Western physical 20668194 CHD4 Affinity Capture-Western physical 21219611 CHD4 Affinity Capture-Western physical 21219611 CHD4 Reconstituted Complex physical 21219611 CHD4 Biochemical Activity physical 21219611 SREBF1 Affinity Capture-Western physical 20534441 MDC1 Biochemical Activity physical 18006705 EXO1 Affinity Capture-Western physical 20019063 EXO1 Reconstituted Complex physical 20019063 FANCD2 Biochemical Activity physical 12086603 E2F1 Biochemical Activity physical 11459832 TP53 Biochemical Activity physical 11459832 ABL1 Affinity Capture-Western physical 20798688 TP53 Biochemical Activity physical 21383020 SMC1A Biochemical Activity physical 11877377 TP53 Biochemical Activity physical 19965871 DYRK2 Biochemical Activity physical 19965871 UBC Reconstituted Complex physical 19850743 TRAF6 Reconstituted Complex physical 20932475 ATM Affinity Capture-MS physical 20360068 TCL1A Affinity Capture-Western physical 22065599 TCL1A Reconstituted Complex physical 22065599 CHEK2 Biochemical Activity physical 10973490