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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for APH1A (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001656 metanephros development IEA GO:0006509 membrane protein ectodomain proteolysis IDA GO:0006915 apoptosis TAS GO:0007219 Notch signaling pathway TAS GO:0007220 Notch receptor processing IMP GO:0007220 Notch receptor processing TAS GO:0008624 induction of apoptosis by extracellular signals TAS GO:0016485 protein processing IDA GO:0016485 protein processing IEA GO:0031293 membrane protein intracellular domain proteolysis IMP GO:0031293 membrane protein intracellular domain proteolysis TAS GO:0042987 amyloid precursor protein catabolic process IMP GO:0042987 amyloid precursor protein catabolic process TAS GO:0043085 positive regulation of catalytic activity IDA GO:0043085 positive regulation of catalytic activity IEA GO:0048011 nerve growth factor receptor signaling pathway TAS cellular_component GO:0005783 endoplasmic reticulum IDA GO:0005789 endoplasmic reticulum membrane IEA GO:0005794 Golgi apparatus IDA GO:0005886 plasma membrane TAS GO:0005887 integral to plasma membrane IDA GO:0016021 integral to membrane IEA GO:0032580 Golgi cisterna membrane IEA molecular_function GO:0004175 endopeptidase activity TAS GO:0004190 aspartic-type endopeptidase activity TAS GO:0005515 protein binding IPI GO:0008233 peptidase activity TAS

Protein-protein interaction details for APH1A (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NCSTN Affinity Capture-Western physical 15257293 PSEN1 Affinity Capture-Western physical 14572442 NCSTN Affinity Capture-Western physical 14572442 PSENEN Affinity Capture-Western physical 14572442 NCSTN Affinity Capture-Western physical 14572442 PSEN1 Affinity Capture-Western physical 14572442 PSENEN Affinity Capture-Western physical 14572442 NCSTN Affinity Capture-Western physical 12857757 PSENEN Affinity Capture-Western physical 12740439 NCSTN Co-fractionation physical 12471034 PSEN1 Co-fractionation physical 12471034 PSEN1 Affinity Capture-Western physical 12471034 PSEN1 Affinity Capture-Western physical 12471034 PSEN2 Affinity Capture-Western physical 12471034 NCSTN Affinity Capture-Western physical 12471034 NCSTN Affinity Capture-Western physical 12471034 PSEN1 Affinity Capture-Western physical 12297508 PSEN2 Affinity Capture-Western physical 12297508 NCSTN Affinity Capture-Western physical 12297508 NCSTN Affinity Capture-Western physical 12297508