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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for AURKA (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000278 mitotic cell cycle IEA GO:0000278 mitotic cell cycle TAS GO:0006468 protein phosphorylation IDA GO:0006468 protein phosphorylation IEA GO:0007049 cell cycle NAS GO:0007051 spindle organization NAS GO:0007067 mitosis TAS GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS GO:0031647 regulation of protein stability IMP GO:0032355 response to estradiol stimulus IEA GO:0045840 positive regulation of mitosis TAS GO:0046605 regulation of centrosome cycle TAS GO:0046777 protein autophosphorylation TAS GO:0048015 phosphatidylinositol-mediated signaling NAS GO:0051301 cell division IEA cellular_component GO:0005634 nucleus IDA GO:0005737 cytoplasm IEA GO:0005813 centrosome IDA GO:0005813 centrosome IEA GO:0005813 centrosome TAS GO:0005819 spindle IEA GO:0005819 spindle TAS GO:0005829 cytosol TAS GO:0005856 cytoskeleton IEA GO:0005876 spindle microtubule IDA GO:0030496 midbody TAS GO:0031616 spindle pole centrosome IDA GO:0048471 perinuclear region of cytoplasm IDA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IDA GO:0004674 protein serine/threonine kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity TAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016301 kinase activity IEA GO:0019901 protein kinase binding IPI GO:0031625 ubiquitin protein ligase binding IEA

Protein-protein interaction details for AURKA (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID RAB10 Affinity Capture-MS physical 17353931 CDKN2A Affinity Capture-MS physical 17353931 SOD2 Affinity Capture-MS physical 17353931 UBE2L3 Affinity Capture-MS physical 17353931 BRCA1 Affinity Capture-Western physical 14990569 BRCA1 Reconstituted Complex physical 14990569 TACC1 Affinity Capture-Western physical 15064709 TACC1 Affinity Capture-Western physical 14603251 NIN Biochemical Activity physical 12927815 UBE2N Reconstituted Complex physical 12881723 UBE2N Affinity Capture-Western physical 12881723 MBD3 Affinity Capture-Western physical 12354758 MBD3 Biochemical Activity physical 12354758 NME1 Two-hybrid physical 12490715 NME1 Affinity Capture-Western physical 12490715 NME1 Affinity Capture-Western physical 12490715 NME1 Co-fractionation physical 12490715 CDC20 Affinity Capture-Western physical 10377410 TP53 Two-hybrid physical 12198151 TP53 Affinity Capture-Western physical 12198151 TP53 Affinity Capture-Western physical 12198151 TP53 Reconstituted Complex physical 12198151 TP53 Phenotypic Suppression genetic 12198151 TPX2 Affinity Capture-Western physical 12177045 TPX2 Reconstituted Complex physical 12177045 CHFR Affinity Capture-Western physical 18592005 KIF2C Biochemical Activity physical 18434591 UBE2N Biochemical Activity physical 17060341 NFKBIA Reconstituted Complex physical 17060341 INCENP Reconstituted Complex physical 18773538 INCENP Affinity Capture-Western physical 18773538 TPX2 Affinity Capture-Western physical 18773538 PLK1 Affinity Capture-Western physical 18773538 INCENP Affinity Capture-Western physical 18773538 TPX2 Reconstituted Complex physical 14600264 TP53 Reconstituted Complex physical 14702041 TP53 Reconstituted Complex physical 14702041 TP53 Affinity Capture-Western physical 14702041 TP53 Affinity Capture-Western physical 14702041 INCENP Affinity Capture-Western physical 11050385 INCENP Reconstituted Complex physical 11050385 TLK1 Affinity Capture-Western physical 17940067 TLK2 Affinity Capture-Western physical 17940067 TLK1 Biochemical Activity physical 17940067 TLK2 Biochemical Activity physical 17940067 HDAC6 Biochemical Activity physical 17604723 HDAC6 Reconstituted Complex physical 17604723 HDAC2 Reconstituted Complex physical 17604723 RASSF1 Biochemical Activity physical 21874044 RASSF1 Biochemical Activity physical 21874044 FBXW7 Affinity Capture-Western physical 19111882 MYCN Affinity Capture-Western physical 19111882 PUM2 Affinity Capture-Western physical 21589936 PUM2 Affinity Capture-Western physical 21589936 PUM2 Reconstituted Complex physical 21589936 AURKA Affinity Capture-MS physical 20360068 CALU Affinity Capture-MS physical 20360068 TPX2 Affinity Capture-MS physical 20360068 Cep192 Affinity Capture-MS physical 20360068 SUMO1 Reconstituted Complex physical 21554500 HIST3H3 Biochemical Activity physical 21554500