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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for AXIN2 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001934 positive regulation of protein phosphorylation IMP GO:0001957 intramembranous ossification IBA GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IEA GO:0007275 multicellular organismal development IEA GO:0008285 negative regulation of cell proliferation IMP GO:0009950 dorsal/ventral axis specification IBA GO:0010718 positive regulation of epithelial to mesenchymal transition IMP GO:0010942 positive regulation of cell death IMP GO:0030111 regulation of Wnt receptor signaling pathway IEA GO:0030282 bone mineralization IEA GO:0032423 regulation of mismatch repair IMP GO:0034613 cellular protein localization IDA GO:0035414 negative regulation of catenin import into nucleus IMP GO:0042476 odontogenesis IMP GO:0043547 positive regulation of GTPase activity IBA GO:0043570 maintenance of DNA repeat elements IMP GO:0045668 negative regulation of osteoblast differentiation IBA GO:0045860 positive regulation of protein kinase activity IEA GO:0048255 mRNA stabilization IMP GO:0061181 regulation of chondrocyte development IEA GO:0070602 regulation of centromeric sister chromatid cohesion IMP GO:0071407 cellular response to organic cyclic compound IBA GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IDA GO:0090090 negative regulation of canonical Wnt receptor signaling pathway IMP GO:0090244 Wnt receptor signaling pathway involved in somitogenesis IBA GO:2000054 negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification IEA cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IDA GO:0005737 cytoplasm IDA GO:0005813 centrosome IDA GO:0005881 cytoplasmic microtubule IBA GO:0005886 plasma membrane IBA GO:0005938 cell cortex IBA GO:0014069 postsynaptic density IBA GO:0016023 cytoplasmic membrane-bounded vesicle IBA GO:0034747 Axin-APC-beta-catenin-GSK3B complex IBA GO:0034747 Axin-APC-beta-catenin-GSK3B complex NAS molecular_function GO:0004871 signal transducer activity IEA GO:0005096 GTPase activator activity IBA GO:0008013 beta-catenin binding IBA GO:0008013 beta-catenin binding NAS GO:0019899 enzyme binding IPI GO:0019901 protein kinase binding IBA GO:0031625 ubiquitin protein ligase binding IPI GO:0070016 armadillo repeat domain binding IBA GO:0070411 I-SMAD binding IEA

Protein-protein interaction details for AXIN2 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID APC2 Two-hybrid physical 10021369 CTNNB1 Affinity Capture-Western physical 10966653 APC Affinity Capture-Western physical 10966653 GSK3B Affinity Capture-Western physical 10966653 ANKRD6 Affinity Capture-Western physical 12183362 ANKRD6 Affinity Capture-Western physical 12183362 GSK3B Affinity Capture-Western physical 12183362 ANKRD6 Two-hybrid physical 12183362 KDM5B Affinity Capture-MS physical 19336002