Gene information for BCL2L10 (Homo sapiens)
(Information is obtained from NCBI Gene database)
| Entrez gene ID | 10017 |
| Official gene symbol | BCL2L10 |
| Full name | BCL2-like 10 (apoptosis facilitator) |
| Aliases | ,BCL-B,Boo,Diva,MGC129810,MGC129811, |
| Gene summary | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq] |
| Location | Chromosome: 15 Locus: |
| Gene position | 52404972 - 52401822 Map Viewer |
| OMIM ID | 606910 |
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