Gene information for CDKN1B (Homo sapiens)
(Information is obtained from NCBI Gene database)
| Entrez gene ID | 1027 |
| Official gene symbol | CDKN1B |
| Full name | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Aliases | ,CDKN4,KIP1,MEN1B,MEN4,P27KIP1, |
| Gene summary | This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq] |
| Location | Chromosome: 12 Locus: |
| Gene position | 12870302 - 12875305 Map Viewer |
| OMIM ID | 600778 |
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