Gene information for METAP2 (Homo sapiens)
(Information is obtained from NCBI Gene database) |
Entrez gene ID | 10988 |
Official gene symbol | METAP2 |
Full name | methionyl aminopeptidase 2 |
Aliases | ,MAP2,MNPEP,p67,p67eIF2, |
Gene summary | This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq] |
Location | Chromosome: 12 Locus: |
Gene position | 95867822 - 95909615 Map Viewer |
OMIM ID | 601870 |