Gene information for CYBB (Homo sapiens)
(Information is obtained from NCBI Gene database)
| Entrez gene ID | 1536 |
| Official gene symbol | CYBB |
| Full name | cytochrome b-245, beta polypeptide |
| Aliases | ,CGD,GP91-1,GP91-PHOX,GP91PHOX,NOX2,p91-PHOX, |
| Gene summary | Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq] |
| Location | Chromosome: X Locus: |
| Gene position | 37639270 - 37672714 Map Viewer |
| OMIM ID | 300481 |
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