Gene information for SF3B1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
| Entrez gene ID | 23451 |
| Official gene symbol | SF3B1 |
| Full name | splicing factor 3b, subunit 1, 155kDa |
| Aliases | ,Hsh155,PRP10,PRPF10,SAP155,SF3b155, |
| Gene summary | This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] |
| Location | Chromosome: 2 Locus: |
| Gene position | 198299771 - 198256698 Map Viewer |
| OMIM ID | 605590 |
|
|
